Cochrane · systematic review · CD007543
Enhanced glucose control for preventing and treating diabetic neuropathy
Callaghan, BC, Little, AA, Feldman, EL, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
NeuromuscularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
10
No studies
2
Included studies
NR
No studies 2 · 15.4%Ungraded 1 · 7.7%Very low 0 · 0%Low 0 · 0%Moderate 3 · 23.1%High 7 · 53.8%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Enhanced glucose control for diabetic neuropathy in type 1 diabetes
Population: patients with diabetic neuropathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of clinical neuropathy after 5 years: risk ratio | RR 0.46 [0.33, 0.63] | 3 studies · 1228 participants | High |
Annual change in peroneal nerve motor conduction velocity m/sec | no estimate extracted | 4 studies · 1371 participants | High |
Annual change in median nerve motor conduction velocity | no estimate extracted | 2 studies · 1241 participants | High |
Annual change in ulnar nerve motor conduction velocity | no estimate extracted | 2 studies · 134 participants | Moderate |
Annual change in vibration threshold in the feet | no estimate extracted | 3 studies · 177 participants | High |
Adverse events | no estimate extracted | NR | No studies |
Wide 95% CI. | no estimate extracted | 1 participants | Ungraded |
Enhanced glucose control for diabetic neuropathy in type 2 diabetes
Population: patients with diabetic neuropathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Annual incidence of clinical neuropathy: risk ratio | no estimate extracted | 4 studies · 6669 participants | High |
Annual change in median nerve motor conduction velocity | no estimate extracted | 1 study · 99 participants | Moderate Downgraded: imprecision |
Annual change in vibration threshold in the feet | no estimate extracted | 1 study · 99 participants | Moderate Downgraded: imprecision |
Death | RR 1.26 [1.06, 1.51] | 1 study · 10251 participants | High |
Weight gain | RR 1.96 [1.81, 2.13] | 1 study · 10078 participants | High |
Other adverse events | no estimate extracted | NR | No studies |