Cochrane · systematic review · CD007179
Antibiotics for treating human brucellosis
Yousefi‐Nooraie, R, Mortaz‐Hejri, S, Mehrani, M, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 3 · 50%Moderate 2 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Doxycycline+Rifampicin compared to Doxycycline+Streptomycin for human Brucellosis
Population: patients with human Brucellosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
total treatment failure Doxycycline+Rifampicin vs Doxycycline+Streptomycin | RR 1.91 [1.07, 3.42] | 7 studies · 567 participants | Moderate Downgraded: risk of bias, imprecision |
Minor adverse drug reactions Doxycycline+Rifampicin vs Doxycycline+Streptomycin | RR 1.38 [0.99, 1.92] | 5 studies · 473 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Doxycycline+Rifampicin compared to Quinolones+Rifampicin for human Brucellosis
Population: patients with human Brucellosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
total treatment failure Doxycycline+Rifampicin vs Quinolones+Rifampicin | OR 0.94 [0.45, 1.98] | 3 studies · 181 participants | Moderate Downgraded: risk of bias |
Minor adverse drug reactions Doxycycline+Rifampicin vs Quinolones+Rifampicin | RR 1.8 [0.78, 4.18] | 4 studies · 296 participants | Low Downgraded: risk of bias, publication bias |
Doxycycline+Streptomycin compared to Doxycycline+Gentamycin for human Brucellosis
Population: patients with human Brucellosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
total treatment failure Doxycycline+Streptomycin vs Doxycycline+Gentamycin | OR 1.85 [0.84, 4.08] | 2 studies · 345 participants | Low Downgraded: indirectness |
Minor adverse drug reactions Doxycycline+Streptomycin vs Doxycycline+Gentamycin | RR 0.85 [0.6, 1.22] | 2 studies · 345 participants | Very low Downgraded: indirectness |