Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Epinephrine vs epinephrine and any second endoscopic method

Mortality rate Number of deaths (30‐day mortality or in‐hospital mortality) · patients with high‐risk bleeding ulcers

Epinephrine probably leads to lower mortality rate Number of deaths (30‐day mortality or in‐hospital… compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Death ‐ at 30 days after ICU admission, in total population randomised · critically ill patients

Intensive insulin therapy showed no clear difference in death ‐ at 30 days after ICU admission, in total population randomised compared with conventional insulin therapy (high certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Death ‐ at 180 days after ICU admission, in total population randomised · critically ill patients

Intensive insulin therapy showed no clear difference in death ‐ at 180 days after ICU admission, in total population… compared with conventional insulin therapy (moderate certainty).

1 finding from 1 review

Infiltration injection local anaesthetic vs no local anaesthetic wound infiltration

Proportion discharged as day surgery · patients with people undergoing laparoscopic cholecystectomy.

It is very uncertain whether local anaesthetic wound infiltration changes proportion discharged as day surgery compared with no local anaesthetic wound infiltration (very low certainty).

1 finding from 1 review