Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,310 questions · 1,358 findings · 214 reviews

No studies found 230 · 16.9%GRADE not reported 169 · 12.4%Very low 269 · 19.8%Low 277 · 20.4%Moderate 291 · 21.4%High 122 · 9%

Intervention not reported

Disability: modified Rankin Scale (mRS) A measure of disability, with 6 categories: 0 (no symptoms), 1 (no significant disability), 2 (slight disability), 3 (moderate disability), 4 (moderately severe disability), 5 (severe disability), 6 (dead); ... · adults with stroke
1 finding from 1 review

Morphine vs placebo

Any pain‐related outcome (moderate pain improvement) · adults with neuropathic pain

It is very uncertain whether morphine changes any pain‐related outcome (moderate pain improvement) compared with placebo (very low certainty).

1 finding from 1 review

NSAIDs vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with fibromyalgia

It is very uncertain whether NSAID changes moderate pain relief: at least 30% reduction in pain, or PGIC much… compared with placebo (very low certainty).

1 finding from 1 review

Methadone vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with chronic neuropathic pain
1 finding from 1 review

G‐CSF vs placebo or no treatment

Oral mucositis (moderate to severe) · Adults with cancer receiving treatment

It is very uncertain whether granulocyte-colony stimulating factor (G-CSF) changes oral mucositis (moderate to severe) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse outcomes ‐ corneal haze score at 12 months (grade 1.0 ‐ more prominent haze that does not interfere with visibility of fine iris details; grade 2.0 ‐ mild obscuration of iris details; grade 3.0 ‐ moderate obscuration of iris and lens; and ... · adult participants (≥ 18 years) with myopia
1 finding from 1 review

Oxycodone MR vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)
1 finding from 1 review

Oral hydromorphone vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with chronic neuropathic pain

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Moderate benefit: at least 30% reduction in pain, or PGIC much or very much improved · Adults with chronic neuropathic pain
1 finding from 1 review