Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,181 questions · 1,197 findings · 144 reviews

No studies found 196 · 16.4%GRADE not reported 213 · 17.8%Very low 274 · 22.9%Low 296 · 24.7%Moderate 171 · 14.3%High 47 · 3.9%

Linezolid vs no linezolid

Number of women who completed treatment ‐ total · drug‐resistant pulmonary tuberculosis

It is very uncertain whether linezolid changes treatment completed compared with no linezolid (very low certainty).

1 finding from 1 review

Linezolid vs no linezolid

Antituberculous treatment discontinuationj · drug‐resistant pulmonary tuberculosis

It is very uncertain whether linezolid changes antituberculous treatment discontinuationj compared with no linezolid (very low certainty).

1 finding from 1 review

Specific antipsychotic vs other drugs

Leaving the study early · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether specific antipsychotic changes acceptability of the treatment: leaving the study early compared with other drugs (very low certainty).

1 finding from 1 review

Cognitive‐behavioural coping skills training (CBCST) vs Twelve Step Facilitation

Number of participants achieving 3 or more weeks of consecutive alcohol abstinence during treatment · concurrent problem alcohol and illicit drug users

It is very uncertain whether cognitive‐behavioural coping skills training (CBCST) changes number of participants achieving 3 or more weeks of consecutive… compared with twelve‐step facilitation (TSF) programme to reduce alcohol consumption (very low certainty).

1 finding from 1 review

Brief motivational interviewing (BMI) vs assessment‐only to reduce alcohol consumption

Retention [ · concurrent problem alcohol and illicit drug users

Brief motivational interviewing (BMI) showed no clear difference in retention ‐ end of treatment compared with assessment‐only to reduce alcohol consumption (moderate certainty).

1 finding from 1 review

Motivational interviewing intensive (MII) vs motivational interviewing (MI) to reduce alcohol consumption

Retention [ · concurrent problem alcohol and illicit drug users

Motivational interviewing intensive (MII) may leads to higher retention ‐ end of treatment compared with motivational interviewing (MI) to reduce alcohol consumption (low certainty).

1 finding from 1 review

Cognitive‐behavioural coping skills training (CBCST) vs Twelve Step Facilitation

Retention [ · concurrent problem alcohol and illicit drug users

It is very uncertain whether cognitive‐behavioural coping skills training (CBCST) changes retention ‐ end of treatment compared with twelve‐step facilitation (TSF) programme to reduce alcohol consumption (very low certainty).

1 finding from 1 review

Tricyclic antidepressants vs Other Drug for

Number not achieving 14 consecutive dry nights at the end of treatment ‐ amitriptyline vs placebo · children with nocturnal enuresis

It is very uncertain whether tricyclics changes number not achieving 14 consecutive dry nights at the end of… compared with another drug (very low certainty).

2 findings from 1 review

FLUPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

FLUPHENAZINE showed no clear difference in acceptability of treatment‐leaving the study early due to any reason compared with LOW‐POTENCY ANTIPSYCHOTIC DRUGS (moderate certainty).

1 finding from 1 review

PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

It is very uncertain whether comparison 1: PERPHENAZINE changes acceptability of treatment ‐ leaving the study early due to any reason compared with LOW‐POTENCY ANTIPSYCHOTIC DRUGS (very low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

Trifluoperazine showed no clear difference in leaving the study early: 1. Acceptability of treatment ‐ leaving… compared with low‐potency antipsychotic drugs (low certainty).

1 finding from 1 review