Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Ursodeoxycholic acid vs placebo or no treatment

All‐cause mortality at 100 days post‐transplant · Patients undergoing stem cell transplant with malignant and non‐malignant diseases

Summary of findings: Ursodeoxycholic acid may leads to lower all‐cause mortality at 100 days post‐transplant ( compared with placebo or no treatment (low certainty).

1 finding from 1 review

Heparin vs no treatment

All‐cause mortality at 100 days post‐transplant · People undergoing autologous or HLA identical allogeneic bone marrow transplant with a variety of malignant diseases or aplastic anaemia

Summary of findings: Heparin showed no clear difference in all‐cause mortality at 100 days post‐transplant ( compared with no treatment (low certainty).

1 finding from 1 review

Antihistamines vs placebo

Change in severity of overall symptoms: intermediate‐term (3 to 4 days) Subjective severity score · patients with common cold

Antihistamines showed no clear difference in change in severity of overall symptoms: intermediate‐term (3 to 4… compared with placebo (high certainty).

1 finding from 1 review

Antihistamines vs placebo

Change in severity of overall symptoms: long‐term (6 to 10 days) Subjective severity score · patients with common cold

Antihistamines showed no clear difference in change in severity of overall symptoms: long‐term (6 to 10 days)… compared with placebo (high certainty).

1 finding from 1 review

Sedating antihistamines vs placebo

Change in severity of overall symptoms: short‐term (1 to 2 days) Subjective severity score · patients with common cold

Sedating antihistamines leads to lower change in severity of overall symptoms: short‐term (1 to 2 days)… compared with placebo (high certainty).

1 finding from 1 review

Sedating antihistamines vs placebo

Change in severity of overall symptoms: long‐term (6 to 10 days) Subjective severity score · patients with common cold

Sedating antihistamines showed no clear difference in change in severity of overall symptoms: long‐term (6 to 10 days)… compared with placebo (high certainty).

1 finding from 1 review

Planned early birth vs expectant management

Perinatal mortality (stillbirth ‐ death of fetus prior to birth; neonatal death ‐ death within the first 28 days of birth; or infant death ‐ death after the first 28 days) · pregnant women with a term suspected compromised baby
1 finding from 1 review

Intervention not reported

Number of subjects who develop any adverse event (42 days to 10 months) · adults with asymptomatic bacteriuria

The intervention probably leads to higher number of subjects who develop any adverse event (42 days to 10… (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of subjects with bacteriological cure (42 days to 4 years) · adults with asymptomatic bacteriuria

The intervention probably leads to higher number of subjects with bacteriological cure (42 days to 4 years) (moderate certainty).

1 finding from 1 review

Tacrolimus 0.03% vs corticosteroids

Physician's assessment of global response of improvement, clear or excellent ‐ 6 weeks · people with atopic dermatitis

Tacrolimus 0.03% probably leads to higher physician's assessment of global response of improvement, clear or… compared with corticosteroids (moderate certainty).

4 findings from 1 review
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Tacrolimus 0.03% vs corticosteroids

Participant's self‐assessment of global response of improvement: tacrolimus 0.03% 2x/day versus hydrocortisone acetate 1% 2x/day · people with atopic dermatitis

Tacrolimus 0.03% probably leads to higher participant's self‐assessment of global response of improvement:… compared with corticosteroids (moderate certainty).

1 finding from 1 review

Viral influenza vaccine vs control

Infant death (up to 175 days) · Pregnant women aged 18 to 38 years and an estimated gestation of 20 to 36 weeks.

Viral influenza vaccine showed no clear difference in infant death (up to 175 days) compared with control (moderate certainty).

1 finding from 1 review

Viral influenza vaccine vs control

Neonatal hospitalisation due to sepsis within 28 days of birth · Pregnant women aged 18 to 38 years and an estimated gestation of 20 to 36 weeks.

Viral influenza vaccine showed no clear difference in neonatal hospitalisation due to sepsis within 28 days of birth compared with control (moderate certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Neonatal mortality · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes neonatal death (within 28 days after delivery) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (very low certainty).

1 finding from 1 review