Cochrane · systematic review · CD009345
Antihistamines for the common cold
De Sutter, AIM, Saraswat, A, van Driel, ML · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 20%High 4 · 80%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antihistamines compared to placebo for the common cold
Population: patients with the common cold
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in severity of overall symptoms: short‐term Subjective severity score Antihistamines vs placebo | OR 0.74 [0.6, 0.92] | 3 studies · 1490 participants | Moderate Downgraded: risk of bias |
Change in severity of overall symptoms: intermediate‐term (3 to 4 days) Subjective severity score Antihistamines vs placebo | OR 1.19 [0.67, 2.11] | 1 study · 234 participants | High |
Change in severity of overall symptoms: long‐term (6 to 10 days) Subjective severity score Antihistamines vs placebo | OR 0.71 [0.41, 1.22] | 3 studies · 1551 participants | High |
Sedating antihistamines compared to placebo for the common cold
Population: patients with the common cold
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in severity of overall symptoms: short‐term (1 to 2 days) Subjective severity score Sedating antihistamines vs placebo | OR 0.76 [0.61, 0.95] | 2 studies · 1427 participants | High |
Change in severity of overall symptoms: long‐term (6 to 10 days) Subjective severity score Sedating antihistamines vs placebo | OR 0.71 [0.41, 1.22] | 3 studies · 1551 participants | High |