Cochrane · systematic review · CD009982
Impact of Haemophilus influenzae type B (Hib) and viral influenza vaccinations in pregnancy for improving maternal, neonatal and infant health outcomes
Salam, RA, Das, JK, Dojo Soeandy, C, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 5 · 71.4%High 2 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Viral influenza vaccine compared with control in pregnancy for improving maternal, neonatal and infant health outcomes
Population: Pregnant women aged 18 to 38 years and an estimated gestation of 20 to 36 weeks.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal death Viral influenza vaccine vs control | RR 4.96 [0.24, 103.24] | 1 study · 2116 participants | Moderate Downgraded: imprecision |
Infant death (up to 175 days) Viral influenza vaccine vs control | RR 0.71 [0.37, 1.37] | 1 study · 2049 participants | Moderate Downgraded: imprecision |
Perinatal death (stillbirth + death in first week of life) Viral influenza vaccine vs control | RR 1.32 [0.73, 2.38] | 1 study · 2083 participants | Moderate Downgraded: imprecision |
Any respiratory illness in women Viral influenza vaccine vs control | RR 0.97 [0.91, 1.04] | 1 study · 2116 participants | High |
Any respiratory illness in infants Viral influenza vaccine vs control | RR 1.01 [0.95, 1.07] | 1 study · 2049 participants | High |
Maternal hospitalisation for any infection Viral influenza vaccine vs control | RR 2.27 [0.94, 5.49] | 1 study · 2116 participants | Moderate Downgraded: imprecision |
Neonatal hospitalisation due to sepsis within 28 days of birth Viral influenza vaccine vs control | RR 1.6 [0.73, 3.5] | 1 study · 2049 participants | Moderate Downgraded: imprecision |