Tacrolimus 0.03% vs corticosteroids: Physician's assessment of global response of improvement, clear or excellent ‐ 6 weeks
Tacrolimus 0.03% probably leads to higher physician's assessment of global response of improvement, clear or… compared with corticosteroids (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Tacrolimus 0.03% vs corticosteroids Physician's assessment of global response of improvement, clear or excellent ‐ tacrolimus 0.03% 1x/day versus hydrocortisone acetate 1% 2x/day · people with atopic dermatitis Tacrolimus 0.03% probably leads to higher physician's assessment of global response of improvement, clear or… compared with corticosteroids (moderate certainty). Topical tacrolimus for atopic dermatitis (2015) · Cochrane Headline outcomes only | RR 2.05 [1.36, 3.08] | 1 study · 411 participants | Moderate |
Tacrolimus 0.03% vs corticosteroids Physician's assessment of global response of improvement, clear or excellent ‐ tacrolimus 0.03% 2x/day versus hydrocortisone acetate 1% 2x/day · people with atopic dermatitis Tacrolimus 0.03% probably leads to higher physician's assessment of global response of improvement, clear or… compared with corticosteroids (moderate certainty). Topical tacrolimus for atopic dermatitis (2015) · Cochrane Headline outcomes only | RR 2.58 [1.96, 3.38] | 2 studies · 790 participants | Moderate |
Tacrolimus 0.03% vs corticosteroids Physician's assessment of global response of improvement, clear or excellent ‐ tacrolimus 0.03% 2x/day versus corticosteroids moderate‐potency 2x/day · people with atopic dermatitis It is very uncertain whether tacrolimus 0.03% changes physician's assessment of global response of improvement, clear or… compared with corticosteroids (very low certainty). Topical tacrolimus for atopic dermatitis (2015) · Cochrane Headline outcomes only | RR 0.45 [0.13, 1.57] | 2 studies · 409 participants | Very low |
Tacrolimus 0.03% vs corticosteroids Physician's assessment of global response of improvement, clear or excellent ‐ tacrolimus 0.03% 2x/day versus methylprednisolone 0.03% 1x/day · people with atopic dermatitis Tacrolimus 0.03% showed no clear difference in physician's assessment of global response of improvement, clear or… compared with corticosteroids (low certainty). Topical tacrolimus for atopic dermatitis (2015) · Cochrane Headline outcomes only | RR 1 [0.85, 1.19] | 1 study · 265 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Topical tacrolimus for atopic dermatitis 2015 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.