Treatment failure (annual failure rate) by cavity class · Children with carious primary teeth restored in Class-I versus Class-II cavities, no pulp therapy
Class-II restorations failed more than Class-I (annual failure 5-28.9% vs 1.2-14.7% in ART studies); low quality of evidence (ungraded).
1 finding from 1 review
Treatment failure (annual failure rate) · Children (aged 3-8 years) with 2-surface occluso-proximal dentine caries in primary molars, no pulp therapy
Preformed metal (Hall) crowns had a low reported annual failure rate (3.1%) versus compomer (14.7%) in one RCT; low quality of evidence (ungraded).
1 finding from 1 review
Treatment failure (annual failure rate) · Children with previously unrestored, vital carious lesions in primary teeth (no pulp therapy); aged 1.5-11 years
Composite resin (hybrid 0-19.5%; bulk-fill 0-16.9%) performed comparably to or better than most alternatives across 11 RCTs; evidence is of low to unclear quality (ungraded).
1 finding from 1 review
Not applicable (no eligible studies) · Children with carious primary teeth (no pulp therapy)
No eligible RCTs assessed new bio-active restorative materials in carious primary teeth; this is an evidence gap identified by the review.
1 finding from 1 review
Treatment failure (annual failure rate) · Children with previously unrestored, vital carious lesions in primary teeth (no pulp therapy); aged 1.5-11 years
Glass carbomer had very high failure rates (up to 46.2%) in a single RCT, far worse than composite resin or RMGIC; low quality of evidence (ungraded).
1 finding from 1 review
Success rate at 1 year · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…
It is very uncertain whether super ethoxybenzoic acid (Super-EBA) changes success rate at 1 year compared with intermediate restorative material (IRM) (very low certainty).
1 finding from 1 review
RR 0.90 [0.80, 1.01]
1 study
Very low
Success rate at 1 year · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…
It is very uncertain whether dentine-bonded resin composite changes success rate at 1 year (root as unit, per-protocol analysis) compared with glass ionomer cement (very low certainty).
2 findings from 1 review
Success rate at 1 year · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…
It is very uncertain whether glass ionomer cement changes success rate at 1 year compared with amalgam (very low certainty).
1 finding from 1 review
RR 0.98 [0.86, 1.12]
1 study
Very low
Adverse events · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…
The review found no eligible studies for this question.
1 finding from 1 review
Treatment success rate · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…
Mineral trioxide aggregate (MTA) showed no clear difference in success rate at 4 years compared with super ethoxybenzoic acid (Super-EBA); GRADE not reported.
1 finding from 1 review
RR 1.02 [0.93, 1.12]
1 study
GRADE not reported
Overall success rate · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…
Glass ionomer cement showed no clear difference in success rate at 5 years compared with amalgam; GRADE not reported.
1 finding from 1 review
RR 1.00 [0.84, 1.20]
1 study
GRADE not reported
Success rate at 1 year · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…
It is very uncertain whether mineral trioxide aggregate (MTA) changes success rate at 1 year compared with intermediate restorative material (IRM) (very low certainty).
1 finding from 1 review
RR 1.09 [0.97, 1.22]
2 studies
Very low
Adverse events · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…
The review found no eligible studies for this question.
1 finding from 1 review
Change in FEV1 % predicted at end of antibiotic course: absolute post‐treatment values · adults and children with cystic fibrosis
Summary of findings: single showed no clear difference in change in FEV1 % predicted at end of antibiotic course: absolute… compared with combination intravenous anti‐pseudomonal antibiotic therapy (low certainty).
1 finding from 1 review
Time to next course of antibiotics  · adults and children with cystic fibrosis
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Adverse events during treatment · adults and children with cystic fibrosis
The review found no eligible studies for this question.
2 findings from 1 review
Quality of life · adults and children with cystic fibrosis
1 finding from 1 review
Change in sputum P aeruginosa density at end of treatment (cfu/g) · adults and children with cystic fibrosis
Summary of findings: single showed no clear difference in change in sputum P aeruginosa density at end of treatment (cfu/g) compared with combination intravenous anti‐pseudomonal antibiotic therapy (moderate certainty).
2 findings from 1 review
Need for extra treatment · adults and children with cystic fibrosis
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found