Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,062 questions · 1,113 findings · 171 reviews · Headline outcomes only

No studies found 161 · 14.5%GRADE not reported 41 · 3.7%Very low 269 · 24.2%Low 321 · 28.8%Moderate 252 · 22.6%High 69 · 6.2%

Acupuncture vs sham

Multiple pregnancy rate · polycystic ovarian syndrome

True acupuncture showed no clear difference in multiple pregnancy rate compared with sham acupuncture (low certainty).

1 finding from 1 review

Ultrasound‐guided transvaginal ovarian needle drilling with gonadotropin (Gn) vs Gn

Multiple pregnancy rate · clomiphene‐resistant polycystic ovarian syndrome in subfertile women

It is very uncertain whether ultrasound‐guided transvaginal ovarian needle drilling with… changes multiple pregnancy rate (per woman) compared with gn (very low certainty).

1 finding from 1 review

Intervention not reported

Global quality of life FLIC total score (Blanchard 1996), FACT‐G total score (Northouse 2007). Additional studies (reported in comments section): FACT‐B physical functioning subscale (Baucom 2009). EPIC multiple subscales and overall scores (Campb... · individuals with cancer (patients)
1 finding from 1 review

Intervention not reported

Global quality of life score Multiple measures used. WHO‐Five‐Wellbeing Index (Ledderer 2013) FACT‐G total score (Northouse 2007). Additional study (reported in comments section): SF20 subscales (Blanchard 1996). Higher scores indicate better QoL · informal caregivers of people affected by cancer
1 finding from 1 review

Intervention not reported

Any depression Multiple measures used. CES‐D (Blanchard 1996; Kozachik 2001; Kuijer 2004; Kurtz 2005; McCorkle 2007). POMS Depression subscale (Bultz 2000; Campbell 2007). HADS‐D (Nicolaisen 2018; Robertson 2016). Additional study (reported in com... · informal caregivers of people affected by cancer
1 finding from 1 review

Intervention not reported

Any depression Multiple measures used. CES‐D (Blanchard 1996;McCorkle 2007). POMS Depression subscale (Bultz 2000). HADS‐D (Nicolaisen 2018; Robertson 2016). Higher scores indicate higher levels of depression. Folllow‐up: Three to six months post‐... · informal caregivers of people affected by cancer
1 finding from 1 review

Recombinant follicle stimulating hormone vs urinary‐derived gonadotrophins

Multiple pregnancy rate · ovulation induction in polycystic ovarian syndrome

Recombinant follicle stimulating hormone showed no clear difference in incidence of multiple pregnancy (per woman) compared with urinary‐derived gonadotrophins (low certainty).

1 finding from 1 review

Human menopausal gonadotrophin or highly purified human menopausal gonadotrophin vs urinary follicle stimulating hormone

Multiple pregnancy rate · ovulation induction in polycystic ovarian syndrome

It is very uncertain whether human menopausal gonadotrophin or highly purified human menopausal… changes incidence of multiple pregnancy (per woman) compared with urinary follicle stimulating hormone (very low certainty).

1 finding from 1 review

Long‐term GnRH agonist therapy vs no additional therapy

Multiple pregnancy rate · patients with endometriosis prior to standard IVF/ICSI

It is very uncertain whether long‐term GnRH agonist therapy changes multiple pregnancy rate compared with no additional therapy (very low certainty).

1 finding from 1 review