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What do systematic reviews say?

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Evidence found and GRADE certainty

831 questions · 877 findings · 52 reviews · Effective Practice and Organisation of Care

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No studies found 288 · 32.8%GRADE not reported 30 · 3.4%Very low 210 · 23.9%Low 214 · 24.4%Moderate 97 · 11.1%High 38 · 4.3%

Summary of findings table ‐ Promotion/universal prevention interventions vs control group

QoL · preventing mental disorders
2 findings from 1 review

Summary of findings table ‐ Promotion/universal prevention interventions vs control group

Adverse events at study endpoint · preventing mental disorders
2 findings from 1 review

Summary of findings table ‐ Promotion/universal prevention interventions vs control group

Psychological functioning and impairment at study endpoint (higher score = higher disability) · preventing mental disorders
2 findings from 1 review

Summary of findings table ‐ Promotion/universal prevention interventions vs control group

Depressive symptoms · preventing mental disorders
2 findings from 1 review

Summary of findings table ‐ Promotion/universal prevention interventions vs control group

Anxiety · preventing mental disorders
2 findings from 1 review

Summary of findings table ‐ Promotion/universal prevention interventions vs control group

Distress/PTSD symptoms at study endpoint (higher score = higher severity) · preventing mental disorders
2 findings from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Prevalence of morphine use · adult patients with substance dependence

It is very uncertain whether primary health professional‐ and community professional‐led… changes prevalence of morphine use compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Quality of life · adult patients with harmful or hazardous alcohol or substance use

The review found no eligible studies for this question.

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Adverse events ‐ death in past 12 months (RR > 1 denotes higher risk of death) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether lay health worker‐led interventions for adult patients with harmful… changes adverse events ‐ deaths (RR < 1 denotes lower risk) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary care physician alerting system and a patient‐directed intervention (education and reminder to see their primary care physician) vs usual care

Bone mineral density · General practitioners/family doctors involved in the management of patients with osteoporosis

Primary care physician alerting system and a patient‐directed… leads to higher bone Mineral Density 1 compared with standard care (high certainty).

1 finding from 1 review

Primary care physician alerting system and a patient‐directed intervention (education and reminder to see their primary care physician) vs usual care

Osteoporosis medication 2 · General practitioners/family doctors involved in the management of patients with osteoporosis

Primary care physician alerting system and a patient‐directed… leads to higher osteoporosis medication 2 compared with standard care (high certainty).

1 finding from 1 review

Medication reconciliation interventions vs usual care

≥ 1 medication discrepancy per participant (dichotomous) · all patients (aged > 18 years) at a transition of care

It is very uncertain whether medication reconciliation interventions changes ≥ 1 medication discrepancy per participant (dichotomous) compared with standard care (very low certainty).

1 finding from 1 review

Medication reconciliation interventions vs usual care

Discrepancies per participant medication · all patients (aged > 18 years) at a transition of care
2 findings from 1 review