Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,138 questions · 1,154 findings · 139 reviews · Headline outcomes only

No studies found 184 · 15.9%GRADE not reported 183 · 15.9%Very low 273 · 23.7%Low 296 · 25.6%Moderate 171 · 14.8%High 47 · 4.1%

PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

It is very uncertain whether comparison 1: PERPHENAZINE changes acceptability of treatment ‐ leaving the study early due to any reason compared with LOW‐POTENCY ANTIPSYCHOTIC DRUGS (very low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

Trifluoperazine showed no clear difference in leaving the study early: 1. Acceptability of treatment ‐ leaving… compared with low‐potency antipsychotic drugs (low certainty).

1 finding from 1 review

Drug‐eluting balloon angioplasty at 6 months vs uncoated balloon angioplasty at 6 months

Target lesion revascularization · patients with in‐stent restenosis of the femoropopliteal arteries

It is very uncertain whether drug‐eluting balloon angioplasty at 6 months changes target lesion revascularization (TLR) compared with uncoated balloon angioplasty at 6 months (very low certainty).

1 finding from 1 review

Drug‐eluting balloon angioplasty at 6 months vs uncoated balloon angioplasty at 6 months

Binary restenosis · patients with in‐stent restenosis of the femoropopliteal arteries

It is very uncertain whether drug‐eluting balloon angioplasty at 6 months changes binary restenosis compared with uncoated balloon angioplasty at 6 months (very low certainty).

1 finding from 1 review

Drug‐eluting balloon angioplasty at 6 months vs uncoated balloon angioplasty at 6 months

Death · patients with in‐stent restenosis of the femoropopliteal arteries

It is very uncertain whether drug‐eluting balloon angioplasty at 6 months changes death compared with uncoated balloon angioplasty at 6 months (very low certainty).

1 finding from 1 review

Drug‐eluting balloon angioplasty at 6 months vs uncoated balloon angioplasty at 6 months

Improvement ≥ 1 Rutherford category · patients with in‐stent restenosis of the femoropopliteal arteries

It is very uncertain whether drug‐eluting balloon angioplasty at 6 months changes improvement ≥ 1 Rutherford category compared with uncoated balloon angioplasty at 6 months (very low certainty).

1 finding from 1 review

Any antihypertensive drug vs placebo or no treatment

Cardiovascular mortality and morbidity Mean duration of 3.7 years · adults 60 years or older with primary hypertension

Antihypertensive drug probably leads to lower cardiovascular mortality and morbidity Mean duration of 3.7 years compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Any antihypertensive drug vs placebo or no treatment

Coronary heart disease mortality + morbidity · adults 60 years or older with primary hypertension

Antihypertensive drug probably leads to lower coronary heart disease mortality and morbidity Mean duration of 2.9… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review