Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Alarm vs miscellaneous treatments

Proportion of children achieving 14 consecutive dry nights by the end of treatment · children with nocturnal enuresis

It is very uncertain whether alarm changes proportion of children achieving 14 consecutive dry nights by the… compared with miscellaneous treatments (very low certainty).

3 findings from 1 review

Early treatment vs expectant management

Proportion of infants receiving any pharmacotherapy for a hemodynamically significant PDA · preterm infants

Early treatment may leads to higher proportion of infants receiving any pharmacotherapy for a… compared with expectant management (low certainty).

1 finding from 1 review

Very early treatment vs expectant management

Proportion of infants receiving any pharmacotherapy for a hemodynamically significant PDA · preterm infants

It is very uncertain whether very early treatment changes proportion of infants receiving any pharmacotherapy for a… compared with expectant management (very low certainty).

1 finding from 1 review

Digital targeted client communication via mobile devices vs standard care or no intervention (pregnant and postpartum women with HIV)

Adherence · pregnant and postpartum women with HIV

Digital targeted client communication via mobile devices may leads to higher health behaviour change: adherence to ARV therapy compared with standard care or no intervention (pregnant and postpartum women with… (low certainty).

1 finding from 1 review

Digital targeted client communication via mobile devices vs digital non‐targeted client communication (pregnant and postpartum women with HIV)

Adherence · pregnant and postpartum women with HIV

Digital targeted client communication via mobile devices may leads to higher health behaviour change: adherence to ARV therapy compared with digital non‐targeted client communication (pregnant and postpartum… (low certainty).

1 finding from 1 review

Intervention not reported

Requirement for renal replacement therapy ( · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…

It is very uncertain whether the intervention changes requirement for renal replacement therapy ( (very low certainty).

1 finding from 1 review

Active vs expectant management of the third stage of labour (all women)

Neonatal jaundice requiring phototherapy or exchange transfusion · all women who expected a vaginal birth at 24 weeks' gestation or later and their babies

It is very uncertain whether active changes neonatal jaundice requiring phototherapy or exchange transfusion compared with expectant management of the third stage of labour (all women) (very low certainty).

1 finding from 1 review

Prebiotic vs no prebiotics

Treatment with phototherapy · Neonates, including term neonates (gestational age ≥ 37 weeks), late preterm neonates (35 to 37 weeks' gestation) and preterm neonates (<…

Feeding supplementation with prebiotics may leads to lower treatment with phototherapy compared with no prebiotics (low certainty).

1 finding from 1 review