Cochrane · systematic review · CD011393
Interventions for itch in people with advanced chronic kidney disease
Hercz, D, Jiang, SH, Webster, AC · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
32
current version
GRADE rated
32
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 18.8%Low 19 · 59.4%Moderate 4 · 12.5%High 3 · 9.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Pharmacological interventions versus placebo for the relief of itch in people with advanced chronic kidney disease
Population: uraemic pruritus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
GABA analogue VAS(0 to 10 cm) Pharmacological interventions vs placebo | no estimate extracted | 5 studies · 297 participants | High |
Ondansetron VAS(0 to 10 cm) Pharmacological interventions vs placebo | no estimate extracted | 3 studies · 183 participants | High |
Kappa‐opioid agonist VAS(0 to 10 cm) Pharmacological interventions vs placebo | no estimate extracted | 5 studies · 661 participants | High |
Mu‐opioid antagonist VAS(0 to 10 cm) Pharmacological interventions vs placebo | no estimate extracted | 2 studies · 62 participants | Low Downgraded: imprecision |
Nalbuphine VAS(0 to 10 cm) Pharmacological interventions vs placebo | no estimate extracted | 1 study · 179 participants | Low Downgraded: imprecision, inconsistency |
Cromolyn VAS(0 to 10 cm) Pharmacological interventions vs placebo | no estimate extracted | 1 study · 40 participants | Low Downgraded: imprecision |
Nicotinamide VAS(0 to 5 cm) Pharmacological interventions vs placebo | no estimate extracted | 1 study · 50 participants | Low Downgraded: imprecision |
EPO Duo score(0 to 40) Pharmacological interventions vs placebo | no estimate extracted | 1 study · 20 participants | Very low Downgraded: imprecision |
Cholestyramine 0 to 3 severity scale Pharmacological interventions vs placebo | no estimate extracted | 2 studies · 15 participants | Low Downgraded: imprecision |
Montelukast Duo score (0 to 81) and VAS (0 to 10 cm) Pharmacological interventions vs placebo | no estimate extracted | 2 studies · 87 participants | Moderate Downgraded: imprecision, inconsistency |
Sertraline VAS(0 to 10 cm) Pharmacological interventions vs placebo | no estimate extracted | 1 study · 46 participants | Low Downgraded: imprecision |
Lidocaine Itch relief Pharmacological interventions vs placebo | no estimate extracted | 1 study · 16 participants | Very low Downgraded: imprecision |
Sodium thalidomide Itch relief Pharmacological interventions vs placebo | no estimate extracted | 1 study · 33 participants | Very low Downgraded: imprecision |
Doxepin Itch relief Pharmacological interventions vs placebo | no estimate extracted | 1 study · 48 participants | Low Downgraded: imprecision |
Topical treatments versus placebo for the relief of itch in people with advanced chronic kidney disease
Population: uraemic pruritus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Capsaicin cream VAS and Duo’s score Topical treatments vs placebo | no estimate extracted | 2 studies · 112 participants | Moderate |
Pramoxine lotion VAS(0 to 10 cm) Topical treatments vs placebo | no estimate extracted | 1 study · 27 participants | Very low Downgraded: imprecision |
Calcineurin inhibitor VAS(0 to 10 cm) Topical treatments vs placebo | no estimate extracted | 2 studies · 80 participants | Very low Downgraded: imprecision |
Dead Sea lotion 1 to 5 severity score Topical treatments vs placebo | no estimate extracted | 1 study · 41 participants | Very low Downgraded: imprecision |
Cromolyn cream VAS (0 to 5 cm) Topical treatments vs placebo | no estimate extracted | 1 study · 60 participants | Low Downgraded: imprecision |
Baby oil Itch Severity Scale(0 to 21) Topical treatments vs placebo | no estimate extracted | 2 studies · 125 participants | Low Downgraded: imprecision |
L‐arginine salve 0 to 3 severity score Topical treatments vs placebo | no estimate extracted | 1 study · 48 participants | Low Downgraded: imprecision |
Polyunsaturated fatty acids VAS (0 to 10 cm) Duo score Topical treatments vs placebo | no estimate extracted | 2 studies · 78 participants | Low Downgraded: imprecision |
Supplements, haemodialysis modalities, and other treatments for the relief of itch in people with advanced chronic kidney disease
Population: uraemic pruritus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Polyunsaturated fatty acids 0 to 5severity score | no estimate extracted | 1 study · 22 participants | Low Downgraded: imprecision |
L‐carnitine VAS (0 to 6 cm) | no estimate extracted | 1 study · 12 participants | Low Downgraded: imprecision |
Zinc sulfate VAS (0 to 10 cm) | no estimate extracted | 2 studies · 76 participants | Moderate Downgraded: imprecision |
Ergocalciferol 21 point scale | no estimate extracted | 1 study · 50 participants | Low Downgraded: imprecision |
Turmeric Duo score (5 to 40) | no estimate extracted | 1 study · 100 participants | Moderate Downgraded: imprecision |
Fumaria parviflora VAS (0 to 10 cm) | no estimate extracted | 1 study · 63 participants | Low Downgraded: imprecision |
High flux/permeability dialysis VAS (0 to 10 cm) | no estimate extracted | 3 studies · 202 participants | Low Downgraded: imprecision, inconsistency |
HD with haemoperfusion VAS (0 to 10 cm) | no estimate extracted | 1 study · 90 participants | Low Downgraded: imprecision |
UV‐B Duo score, VAS, and %improvement | no estimate extracted | 4 studies · 86 participants | Low Downgraded: imprecision |
Thermal therapy VAS (0 to 10 cm) | no estimate extracted | 1 study · 41 participants | Low Downgraded: imprecision |