Cochrane · systematic review · CD012731
Prebiotics for the prevention of hyperbilirubinaemia in neonates
Armanian, AM, Jahanfar, S, Feizi, A, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 5 · 41.7%Very low 0 · 0%Low 6 · 50%Moderate 0 · 0%High 1 · 8.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Feeding supplementation with prebiotics compared to no prebiotics for the prevention of hyperbilirubinaemia in neonates
Population: Neonates, including term neonates (gestational age ≥ 37 weeks), late preterm neonates (35 to 37 weeks' gestation) and preterm neonates (< 35 weeks' gestation)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of hyperbilirubinaemia Feeding supplementation with prebiotics vs no prebiotics | RR 0.75 [0.58, 0.97] | 1 study · 50 participants | Low Downgraded: risk of bias |
Maximum plasma unconjugated bilirubin levels; Feeding supplementation with prebiotics vs no prebiotics | no estimate extracted | 2 studies · 78 participants | Low Downgraded: risk of bias |
Treatment with phototherapy Feeding supplementation with prebiotics vs no prebiotics | RR 0.75 [0.58, 0.97] | 1 study · 50 participants | Low Downgraded: risk of bias |
Stool frequency Feeding supplementation with prebiotics vs no prebiotics | no estimate extracted | 3 studies · 154 participants | High |
Duration of phototherapy (days) Feeding supplementation with prebiotics vs no prebiotics | no estimate extracted | 1 study · 28 participants | Low Downgraded: risk of bias, imprecision |
Length of hospital stay (days) Feeding supplementation with prebiotics vs no prebiotics | no estimate extracted | 2 studies · 78 participants | Low Downgraded: risk of bias |
Neonatal mortality Feeding supplementation with prebiotics vs no prebiotics | RR 0.94 [0.14, 6.19] | 2 studies · 78 participants | Low Downgraded: risk of bias |
Acute bilirubin encephalopathy (encephalopathy) Feeding supplementation with prebiotics vs no prebiotics | no estimate extracted | 0 studies · 0 participants | Ungraded |
Exchange transfusion (exchange) Feeding supplementation with prebiotics vs no prebiotics | no estimate extracted | 0 studies · 0 participants | Ungraded |
Chronic bilirubin encephalopathy or kernicterus (kernicterus) Feeding supplementation with prebiotics vs no prebiotics | no estimate extracted | 0 studies · 0 participants | Ungraded |
Major neurodevelopmental disability Feeding supplementation with prebiotics vs no prebiotics | no estimate extracted | 0 studies · 0 participants | Ungraded |
Side effects Feeding supplementation with prebiotics vs no prebiotics | no estimate extracted | 0 studies · 0 participants | Ungraded |