Cochrane · systematic review · CD012616
Oral protein‐based supplements versus placebo or no treatment for people with chronic kidney disease requiring dialysis
Mah, JY, Choy, SW, Roberts, MA, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
17
current version
GRADE rated
14
No studies
1
Included studies
NR
No studies 1 · 5.9%Ungraded 2 · 11.8%Very low 6 · 35.3%Low 5 · 29.4%Moderate 3 · 17.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings Table 1
Population: people with CKD requiring dialysis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in serum albumin | no estimate extracted | 16 studies · 790 participants | Moderate Downgraded: inconsistency |
Serum albumin (end of intervention) | no estimate extracted | 14 studies · 715 participants | Moderate Downgraded: inconsistency |
Serum prealbumin | no estimate extracted | 4 studies · 225 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Death | no estimate extracted | NR | No studies |
Intolerance to therapy ‐ Gastrointestinal intolerance | RR 2.81 [0.58, 13.65] | 6 studies · 426 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Summary of findings Table 2
Population: people with CKD requiring dialysis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight | no estimate extracted | 8 studies · 365 participants | Low Downgraded: risk of bias, inconsistency |
Body mass index | no estimate extracted | 9 studies · 368 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Triceps skinfold thickness | no estimate extracted | 6 studies · 367 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Mid‐arm circumference | no estimate extracted | 2 studies · 97 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Mid‐arm muscle circumference | no estimate extracted | 4 studies · 216 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Lean mass | no estimate extracted | 5 studies · 189 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Summary of findings Table 3
Population: people with CKD requiring dialysis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Quality of life | no estimate extracted | 8 studies · 662 participants | Ungraded |
Cost | no estimate extracted | 4 studies · 117 participants | Ungraded |
CRP | no estimate extracted | 8 studies · 436 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
IL‐6 | no estimate extracted | 2 studies · 62 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Serum potassium | no estimate extracted | 7 studies · 357 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Serum phosphate | no estimate extracted | 7 studies · 403 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |