Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

948 questions · 998 findings · 100 reviews · Headline outcomes only

No studies found 233 · 23.3%GRADE not reported 40 · 4%Very low 203 · 20.3%Low 271 · 27.2%Moderate 176 · 17.6%High 75 · 7.5%

B vitamins vs placebo

Supplementation with beta‐carotene + vit C + vit E Overall cognitive functioning · cognitively healthy people in mid and late life
6 findings from 1 review
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Vitamin D3 vs placebo

Cognitive function · cognitively healthy people in mid and late life
2 findings from 1 review

Vitamin D plus calcium vs vitamin D

Adverse events (number) Asymptomatic hypercalcaemia and hypercalciuria

It is very uncertain whether vitamin D plus calcium changes adverse events (number) Definition: asymptomatic hypercalcaemia and… compared with vitamin D (very low certainty).

1 finding from 1 review