Cochrane · systematic review · CD011905
Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment
McCleery, J, Abraham, RP, Denton, DA, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
20
current version
GRADE rated
10
No studies
9
Included studies
NR
No studies 9 · 45%Ungraded 1 · 5%Very low 2 · 10%Low 3 · 15%Moderate 5 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
B vitamins compared to placebo for MCI
Population: MCI
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of dementia ‐ not measured B vitamins vs placebo | no estimate extracted | NR | No studies |
Overall cognitive function B vitamins vs placebo | no estimate extracted | 3 studies · 488 participants | Very low Downgraded: risk of bias, imprecision |
Episodic memory B vitamins vs placebo | no estimate extracted | 3 studies · 397 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Executive function B vitamins vs placebo | no estimate extracted | 3 studies · 392 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Speed of processing B vitamins vs placebo | no estimate extracted | 2 studies · 173 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Quality of life B vitamins vs placebo | no estimate extracted | 1 study · 138 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Mortality ‐ not reported B vitamins vs placebo | no estimate extracted | NR | No studies |
Vitamin E compared to placebo for MCI
Population: MCI
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of dementia due to Alzheimer's disease Vitamin E vs placebo | no estimate extracted | 1 study · 516 participants | Moderate Downgraded: imprecision |
Overall cognitive functioning Vitamin E vs placebo | no estimate extracted | 1 study · 1 participants | Low Downgraded: risk of bias, imprecision |
Episodic memory Vitamin E vs placebo | no estimate extracted | 1 study · 1 participants | Low Downgraded: risk of bias, imprecision |
Executive functioning Vitamin E vs placebo | no estimate extracted | 1 study · 1 participants | Low Downgraded: risk of bias, imprecision |
Quality of life ‐ not measured Vitamin E vs placebo | no estimate extracted | NR | No studies |
Mortality Vitamin E vs placebo | no estimate extracted | 1 study · 1 participants | Ungraded |
Vitamin E + vitamin C compared to placebo for MCI
Population: MCI
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of dementia ‐ not measured Vitamin E + vitamin C vs placebo | no estimate extracted | NR | No studies |
Overall cognitive function Vitamin E + vitamin C vs placebo | no estimate extracted | 1 study · 256 participants | Very low Downgraded: risk of bias |
Episodic memory ‐ not measured Vitamin E + vitamin C vs placebo | no estimate extracted | NR | No studies |
Executive function ‐ not measured Vitamin E + vitamin C vs placebo | no estimate extracted | NR | No studies |
Speed of processing ‐ not measured Vitamin E + vitamin C vs placebo | no estimate extracted | NR | No studies |
Quality of life ‐ not measured Vitamin E + vitamin C vs placebo | no estimate extracted | NR | No studies |
Mortality ‐ not reported Vitamin E + vitamin C vs placebo | no estimate extracted | NR | No studies |