Findings

What do systematic reviews say?

1,126 questions · 1,225 findings · 111 reviews

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No studies found 235 · 19.2%GRADE not reported 260 · 21.2%Very low 207 · 16.9%Low 271 · 22.1%Moderate 177 · 14.4%High 75 · 6.1%

Intervention not reported

Vitamin C plus vitamin E(1 trial; 88 participants) · people with non‐alcohol‐related fatty liver disease (NAFLD)

1 finding from 1 review

Nutritional supplementation for nonalcohol‐related fatty liver disease: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Amino acids plus vitamin C(1 trial; 191 participants) · people with non‐alcohol‐related fatty liver disease (NAFLD)

1 finding from 1 review

Nutritional supplementation for nonalcohol‐related fatty liver disease: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Amino acids + vitamin C(1 RCT; 191 participants) · people with non‐alcohol‐related fatty liver disease (NAFLD)

It is very uncertain whether the intervention changes amino acids + vitamin C(1 RCT; 191 participants) (very low certainty).

1 finding from 1 review

Nutritional supplementation for nonalcohol‐related fatty liver disease: a network meta‐analysis 2021 · Cochrane Headline outcomes only
OR 1.76 [0.62, 5.53]
Studies not reported
Very low

Intervention not reported

Vitamin C adherence · Various (pregnant women; daily smokers aged 16 and older; university students; children aged 5‐13)

1 finding from 1 review

Mobile phone messaging for preventive health care 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 99 participants
Moderate

Higher dose vitamin K vs lower dose vitamin K

Bleeding complications: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in bleeding complications: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 0.12 [0.01, 2.11]
1 study · 54 participants
Low

Higher dose vitamin K vs lower dose vitamin K

Intraventricular hemorrhage > Grade II: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in intraventricular hemorrhage > Grade II: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 0.36 [0.04, 3.24]
1 study · 54 participants
Low

Higher dose vitamin K vs lower dose vitamin K

Presence of PIVKA II at day 5: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in presence of PIVKA II at day 5: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.36 [0.24, 7.57]
1 study · 61 participants
Low

Higher dose vitamin K vs lower dose vitamin K

Presence of PIVKA II at day 25: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in presence of PIVKA II at day 25: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 0.96 [0.06, 14.6]
1 study · 53 participants
Low

Higher dose vitamin K vs lower dose vitamin K

Necrotizing enterocolitis: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in necrotizing enterocolitis: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.08 [0.16, 7.1]
1 study · 54 participants
Low

Higher dose vitamin K vs lower dose vitamin K

Sepsis: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in sepsis: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 0.86 [0.26, 2.86]
1 study · 54 participants
Low

Higher dose vitamin K vs lower dose vitamin K

Mortality (all infants): 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in mortality (all infants): 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 2.13 [0.6, 7.51]
1 study · 65 participants
Low

Pyridoxal 5 phosphate (vitamin B6) vs placebo

Global: Discontinuation of Vitamin B6 · patients with antipsychotic‐induced tardive dyskinesia

Pyridoxal 5 phosphate (vitamin B6) showed no clear difference in global: Discontinuation of Vitamin B6 compared with placebo (low certainty).

1 finding from 1 review

Pyridoxal 5 phosphate for neuroleptic‐induced tardive dyskinesia 2015 · Cochrane Headline outcomes only
RR 8.72 [0.51, 149.75]
2 studies · 65 participants
Low

B vitamins vs placebo

Incidence of dementia ‐ not measured · MCI

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

B vitamins vs placebo

Cognitive function · MCI

1 finding from 1 review

Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 488 participants
Very low

B vitamins vs placebo

Cognitive subdomain: episodic memory measured at the end of · MCI

1 finding from 1 review

Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 397 participants
Moderate

B vitamins vs placebo

Executive function (specific cognitive function) · MCI

1 finding from 1 review

Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 392 participants
Moderate

B vitamins vs placebo

Information processing speed · MCI

1 finding from 1 review

Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 173 participants
Moderate

B vitamins vs placebo

Quality of life · MCI

1 finding from 1 review

Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 138 participants
Moderate

B vitamins vs placebo

Mortality ‐ not reported · MCI

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

B vitamins vs placebo

Supplementation with beta‐carotene + vit C + vit E Overall cognitive functioning · cognitively healthy people in mid and late life

6 findings from 1 review

Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late… 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 2556 participants
Moderate
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late… 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 317 participants
Low
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late… 2018 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 6956 participants
Moderate

Show 3 more findings

Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 241 participants
Low
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late… 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 3985 participants
Moderate
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late… 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 10249 participants
Low