Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,695 questions · 4,979 findings · 433 reviews

No studies found 998 · 20%GRADE not reported 1,140 · 22.9%Very low 1,024 · 20.6%Low 1,029 · 20.7%Moderate 636 · 12.8%High 152 · 3.1%

Zinc vs placebo

Need for antibiotics days of antibiotic use · children with cystic fibrosis

It is very uncertain whether summary of findings: Zinc supplementation changes need for antibiotics number of days on IV or oral antibiotics compared with placebo (very low certainty).

1 finding from 1 review

Any systemic treatment vs placebo

Oral Tyrosine kinase 2 (TYK2) inhibitor · people with chronic plaque psoriasis

Any systemic treatment may leads to higher oral tyrosine kinase 2 (TYK2) inhibitor compared with placebo (low certainty).

2 findings from 1 review

Intervention not reported

Adverse effects Oral glucose tolerance test (mg/dL) (at one year) · people with thalassaemia (any age)
1 finding from 1 review

Primary objective: mobile stock notification with effective product transport vs usual care

Proportion of healthcare workers who reported a stockout of drugs in the last 30 days (stockout of oral rehydration salts (ORS) to treat dehydration) · healthcare workers and other health professionals involved in commodity and stock management

It is very uncertain whether primary objective: mobile stock notification with effective product… changes proportion of healthcare workers who reported a stockout of drugs in… compared with standard care (very low certainty).

1 finding from 1 review

Primary objective: mobile stock notification with enhanced management vs usual care

Proportion of healthcare workers who reported a stockout of drugs in the last 30 days (stockout of oral rehydration salts (ORS) to treat dehydration) · healthcare workers and other health professionals involved in commodity and stock management

It is very uncertain whether primary objective: mobile stock notification with enhanced management changes proportion of healthcare workers who reported a stockout of drugs in… compared with standard care (very low certainty).

1 finding from 1 review

Digital targeted client communication via mobile devices vs non‐digital targeted client communication (parents of children aged under five years)

Health behaviour change – hygiene practices · parents of children aged < 5 years

Digital targeted client communication via mobile devices showed no clear difference in health behaviour change – hygiene practices (oral health in children… compared with non‐digital targeted client communication (parents of children aged… (low certainty).

1 finding from 1 review

Digital targeted client communication via mobile devices vs standard skin care or no skin care intervention

Health behaviour change ‐ Oral contraception use · Adolescents and youth age 14 to 24 years

Digital targeted client communication via mobile devices may leads to higher health behaviour change ‐ Oral contraception use compared with standard care or no intervention (low certainty).

1 finding from 1 review

Any antimicrobial mouthwash and/or nasal spray (alone or in combination), at any concentration, delivered to healthcare workers, with or without the same intervention given to the patients with COVID-19 vs No treatment or saline or water

Other adverse events (allergy, irritation/burning of nasal, oral or oropharyngeal mucosa, long-term staining of mucous membranes or teeth, accidental ingestion) · Healthcare workers (HCWs) treating patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

High-volume evacuation (HVE) vs No HVE

Reduction in level of contamination in aerosols (CFU) during ultrasonic scaling and air polishing at less than 1 foot (~30 cm) from oral cavity (RCTs) · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether high-volume evacuation (HVE) changes reduction in level of contamination in aerosols (CFU) during… compared with no HVE (very low certainty).

1 finding from 1 review

Antimicrobial mouthwash and/or nasal spray (alone or in combination), any concentration, frequency or dosage vs No treatment or saline or water

Changes in microbiome in oral cavity, nasal cavity, oro- or nasopharynx · Patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 1: route of antibiotic vs usual care

Neonatal mortality ‐ oral + injectable antibiotics · neonates with sepsis

Comparison 1: route of antibiotic showed no clear difference in neonatal mortality ‐ oral + injectable antibiotics compared with standard care (moderate certainty).

1 finding from 1 review