Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

643 questions · 671 findings · 87 reviews

No studies found 177 · 26.4%GRADE not reported 106 · 15.8%Very low 182 · 27.1%Low 114 · 17%Moderate 66 · 9.8%High 26 · 3.9%

Intervention not reported

Incidence of a secondary primary breast cancer (e.g. in the contralateral breast) ‐ endocrine therapies not separated (exemestane (AI)/tamoxifen (SERM)/unknown) · women receiving endocrine therapy (selective oestrogen receptor modulator or aromatase inhibitor)
1 finding from 1 review

Intervention not reported

Severe hearing loss defined as a threshold of 60 dB or more in the better ear or requiring bilateral hearing aid during the · children with acute bacterial meningitis

The intervention showed no clear difference in severe hearing loss defined as a threshold of 60 dB or more in the… (low certainty).

1 finding from 1 review

Carotid artery stenting vs endarterectomy

Death or any stroke between randomisation and 30 days after treatment or ipsilateral stroke until end of · people with symptomatic carotid stenosis

Carotid artery stenting leads to higher death or any stroke between randomisation and 30 days after… compared with endarterectomy (high certainty).

1 finding from 1 review

Carotid artery stenting vs endarterectomy

Death or any stroke between randomisation and 30 days after treatment or ipsilateral stroke until end of · asymptomatic carotid stenosis

Carotid artery stenting showed no clear difference in death or any stroke between randomisation and 30 days after… compared with endarterectomy (moderate certainty).

1 finding from 1 review

Intervention not reported

Ipsilateral ischaemic stroke, and any operative stroke or death (five‐year cumulative) · people with carotid stenosis and recent transient ischaemic attacks (TIA) or minor ischaemic strokes in the territory of that artery

The intervention showed no clear difference in ipsilateral ischaemic stroke, and any operative stroke or death… (moderate certainty).

1 finding from 1 review

Intervention not reported

Disabling or fatal ipsilateral ischaemic or operative stroke and death (five‐year cumulative) · people with carotid stenosis and recent transient ischaemic attacks (TIA) or minor ischaemic strokes in the territory of that artery

The intervention showed no clear difference in disabling or fatal ipsilateral ischaemic or operative stroke and… (moderate certainty).

1 finding from 1 review

Lidocaine vs propafenone

Adverse events (AEs; adverse drug reaction): bilateral bundle branch block · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): bilateral bundle branch… compared with propafenone (very low certainty).

1 finding from 1 review

Summary of findings: split‐spinous process laminotomy vs conventional laminectomy

VAS back (0 to 10) Unilateral laminotomy compared with conventional laminectomy · patients with lumbar stenosis

It is very uncertain whether summary of findings: split‐spinous process laminotomy changes VAS back (0 to 10) Unilateral laminotomy compared with conventional… compared with conventional laminectomy (very low certainty).

1 finding from 1 review