Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,087 questions · 2,360 findings · 390 reviews

No studies found 224 · 9.5%GRADE not reported 603 · 25.6%Very low 555 · 23.5%Low 548 · 23.2%Moderate 312 · 13.2%High 118 · 5%

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Disease progression measured by opportunistic disease Opportunistic disease events · patients with asymptomatic, HIV‐infected, treatment naive adults

Early ART showed no clear difference in disease progression measured by opportunistic disease Opportunistic… compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (low certainty).

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Relative abundance of Veillonella spp. · Children under 6 years with severe early childhood caries and caries-free controls

Veillonella spp. mean relative abundance was lower in the S-ECC group; no comparative effect estimate or CI was reported.

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Relative abundance of S. mutans in saliva · Children under 6 years with severe early childhood caries and caries-free controls

S. mutans median relative abundance was higher in the S-ECC group, without a comparative effect estimate or CI.

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Streptococcus relative abundance · Children under 6 years with severe early childhood caries and caries-free controls

Streptococcus mean relative abundance was slightly higher in the S-ECC group; no comparative effect estimate or CI was reported.

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Veillonella spp. and Streptococcus mutans interaction · Children under 6 years with severe early childhood caries and caries-free controls

The study reported a possible role for Veillonella spp. in supporting cariogenic species, without a quantitative effect estimate.

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Veillonella dispar relative abundance · Children under 6 years with severe early childhood caries and caries-free controls

Veillonella dispar median relative abundance was higher in the S-ECC group, without a comparative effect estimate or CI.

1 finding from 1 review

Planned early birth vs expectant management

Admission to neonatal intensive care unit · preterm prelabour rupture of membranes (PPROM)

Planned early birth probably leads to higher admission to neonatal intensive care compared with expectant management (moderate certainty).

1 finding from 1 review

Planned early birth vs expectant management

Length of maternal hospital stay (days) · preterm prelabour rupture of membranes (PPROM)

Planned early birth showed no clear difference in length of hospital stay (maternal) compared with expectant management (moderate certainty).

1 finding from 1 review