Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

379 questions · 472 findings · 38 reviews

No studies found 115 · 24.4%GRADE not reported 157 · 33.3%Very low 89 · 18.9%Low 63 · 13.3%Moderate 36 · 7.6%High 12 · 2.5%

Automated monitoring systems vs usual care

Time to initiation of antimicrobial therapy (Time to initiation starts at the time of admission) · people admitted to intensive care units

It is very uncertain whether automated monitoring systems changes time to initiation of antimicrobial therapy (Time to initiation… compared with standard care (very low certainty).

1 finding from 1 review

Chlorhexidine vs non‐antibacterial

Infection: chlorhexidine versus no antimicrobial/no additional antimicrobial · people with burns

It is very uncertain whether chlorhexidine changes infection: chlorhexidine versus no antimicrobial/no additional… compared with non‐antibacterial (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 1.11 [0.54, 2.27]
    2 studies · 172 participants
    Very low

Early discharge vs non‐early discharge

Treatment failure; rehospitalization or adjustment of antimicrobial treatment (or both) in number of episodes · children with cancer

Early discharge showed no clear difference in treatment failure; rehospitalization or adjustment of antimicrobial… compared with non‐early discharge (low certainty).

1 finding from 1 review

Very early discharge vs early discharge

Treatment failure; rehospitalization or adjustment of antimicrobial treatment (or both) in number of episodes · children with cancer

Very early discharge showed no clear difference in treatment failure; rehospitalization or adjustment of antimicrobial… compared with early discharge (low certainty).

1 finding from 1 review

Very early discharge vs early discharge

Treatment failure; rehospitalization or adjustment of antimicrobial treatment (or both), only first episode in number of participants · children with cancer

Very early discharge showed no clear difference in treatment failure; rehospitalization or adjustment of antimicrobial… compared with early discharge (low certainty).

1 finding from 1 review

Single‐dose antibiotic vs short duration antibiotics

Pyelonephritis ‐ Same antimicrobial agent only4 · patients with asymptomatic bacteriuria during pregnancy

It is very uncertain whether single‐dose antibiotic changes pyelonephritis ‐ Same antimicrobial agent only4 compared with short‐course (four‐ to seven‐day) antibiotic (very low certainty).

1 finding from 1 review

Single‐dose antibiotic vs short duration antibiotics

Low birthweight ‐ Same antimicrobial agent only · patients with asymptomatic bacteriuria during pregnancy

Single‐dose antibiotic leads to higher low birthweight ‐ Same antimicrobial agent only compared with short‐course (four‐ to seven‐day) antibiotic (high certainty).

1 finding from 1 review

Single‐dose antibiotic vs short duration antibiotics

Preterm delivery ‐ Same antimicrobial agent only · patients with asymptomatic bacteriuria during pregnancy

Single‐dose antibiotic showed no clear difference in preterm delivery ‐ Same antimicrobial agent only compared with short‐course (four‐ to seven‐day) antibiotic (moderate certainty).

1 finding from 1 review

Single‐dose antibiotic vs short duration antibiotics

Same antimicrobial agent ‐ No cure (good quality studies) · patients with asymptomatic bacteriuria during pregnancy

Single‐dose antibiotic leads to higher same antimicrobial agent ‐ No cure (good quality studies) compared with short‐course (four‐ to seven‐day) antibiotic (high certainty).

1 finding from 1 review

Single‐dose antibiotic vs short duration antibiotics

Different antimicrobial agents ‐ No cure (good quality studies) · patients with asymptomatic bacteriuria during pregnancy

Single‐dose antibiotic showed no clear difference in different antimicrobial agents ‐ No cure (good quality studies) compared with short‐course (four‐ to seven‐day) antibiotic (low certainty).

1 finding from 1 review