Intervention not reported
It is very uncertain whether the intervention changes serious adverse events during treatment (very low certainty).
- RR 1.05 [0.85, 1.29]15 studies · 1861 participantsVery low
It is very uncertain whether the intervention changes serious adverse events during treatment (very low certainty).
The intervention showed no clear difference in non‐fatal, serious adverse events (all) (moderate certainty).
The intervention showed no clear difference in non‐fatal, serious adverse events (all) (high certainty).
LAMA add‐on showed no clear difference in all‐cause serious adverse events 24 weeks compared with ICS alone (low certainty).
Regular formoterol and ICS showed no clear difference in all‐cause non‐fatal serious adverse events compared with same‐dose ICS (high certainty).
Regular formoterol and ICS showed no clear difference in all‐cause non‐fatal serious adverse events compared with same‐dose ICS (moderate certainty).
Regular formoterol and ICS showed no clear difference in asthma‐related non‐fatal serious adverse events compared with same‐dose ICS (moderate certainty).
It is very uncertain whether regular formoterol and ICS changes asthma‐related non‐fatal serious adverse events compared with same‐dose ICS (very low certainty).
It is very uncertain whether brain‐derived neurotrophic factor changes participants with 1 or more serious adverse events compared with placebo (very low certainty).
It is very uncertain whether cerebrospinal fluid filtration changes participants with 1 or more serious adverse events compared with plasma exchange (very low certainty).
Eculizumab showed no clear difference in participants with 1 or more serious adverse events compared with placebo (low certainty).
It is very uncertain whether interferon beta‐1a changes participants with 1 or more serious adverse events compared with placebo (very low certainty).
The intervention probably leads to higher serious adverse events Duration of trials: 12 to 20 weeks (moderate certainty).
It is very uncertain whether the intervention changes participants with non‐serious adverse events: up to 3 months' (very low certainty).
Intermittent 'as needed' ICS showed no clear difference in patients with serious adverse health events (duration 12 to 52 weeks) compared with daily ICS (low certainty).
It is very uncertain whether the intervention changes serious adverse eventsClinical manifestation and laboratory… (very low certainty).
The intervention leads to higher non‐fatal, serious adverse pneumonia events (requiring hospital… (high certainty).
The intervention showed no clear difference in non‐fatal, serious adverse pneumonia events (requiring hospital… (moderate certainty).
The intervention showed no clear difference in adverse events-serious Mometasone/formoterol (MF/F) versus… (low certainty).
The intervention showed no clear difference in non‐serious adverse eventsClinical manifestation and laboratory… (low certainty).