Cochrane · systematic review · CD011397
Long‐acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus the same dose of ICS alone for adults with asthma
Anderson, DE, Kew, KM, Boyter, AC · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 2 · 28.6%High 3 · 42.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
LAMA add‐on compared with ICS alone for adults with asthma
Population: adults with asthma not well controlled on ICS alone
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbations requiring oral corticosteroids (OCS) LAMA add‐on vs ICS alone | OR 0.65 [0.46, 0.93] | 4 studies · 2277 participants | High |
Quality of life (AQLQ) LAMA add‐on vs ICS alone | no estimate extracted | 3 studies · 1713 participants | High |
All‐cause serious adverse events 24 weeks LAMA add‐on vs ICS alone | OR 0.6 [0.23, 1.57] | 5 studies · 2562 participants | Low Downgraded: imprecision, inconsistency, indirectness |
Exacerbations requiring hospital admission 24 weeks LAMA add‐on vs ICS alone | OR 0.42 [0.12, 1.47] | 5 studies · 2562 participants | Moderate Downgraded: imprecision, inconsistency, indirectness |
Lung function ‐ trough FEV1 (L, change from baseline) LAMA add‐on vs ICS alone | no estimate extracted | 5 studies · 2459 participants | High |
Asthma control (ACQ) LAMA add‐on vs ICS alone | no estimate extracted | 3 studies · 1916 participants | Moderate |
Any adverse events 24 weeks LAMA add‐on vs ICS alone | OR 0.95 [0.8, 1.14] | 5 studies · 2562 participants | Low Downgraded: imprecision, inconsistency, indirectness |