Cochrane · systematic review · CD010115
Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease
Kew, KM, Seniukovich, A · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
12
No studies
2
Included studies
NR
No studies 2 · 14.3%Ungraded 0 · 0%Very low 1 · 7.1%Low 0 · 0%Moderate 6 · 42.9%High 5 · 35.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Fluticasone for chronic obstructive pulmonary disease
Population: patients with chronic obstructive pulmonary disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes | no estimate extracted | NR | No studies |
Non‐fatal, serious adverse pneumonia events (requiring hospital admission) | OR 1.78 [1.5, 2.12] | 17 studies · 19504 participants | High |
Mortality, all‐cause | OR 0.99 [0.87, 1.13] | 22 studies · 20861 participants | High |
Mortality, due to pneumonia | OR 1.23 [0.7, 2.15] | 18 studies · 19532 participants | Moderate Downgraded: imprecision |
Non‐fatal, serious adverse events (all) | OR 1.06 [0.99, 1.14] | 19 studies · 20381 participants | High |
All pneumonia events | OR 1.68 [1.49, 1.9] | 11 studies · 15377 participants | Moderate Downgraded: publication bias |
Withdrawals | OR 0.81 [0.77, 0.86] | 26 studies · 21243 participants | High |
Budesonide for chronic obstructive pulmonary disease
Population: patients with chronic obstructive pulmonary disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes | no estimate extracted | NR | No studies |
Non‐fatal, serious adverse pneumonia events (requiring hospital admission) | OR 1.62 [1, 2.62] | 7 studies · 6472 participants | Moderate Downgraded: inconsistency, publication bias |
Mortality, all‐cause | OR 0.9 [0.65, 1.24] | 12 studies · 10009 participants | Moderate |
Mortality, due to pneumonia | OR 4.46 [0.07, 286.99] | 3 studies · 1511 participants | Very low Downgraded: imprecision, inconsistency, publication bias |
Non‐fatal, serious adverse events (all) | OR 1.01 [0.83, 1.22] | 12 studies · 10009 participants | Moderate |
All pneumonia events | OR 1.12 [0.83, 1.51] | 6 studies · 7011 participants | Moderate Downgraded: inconsistency, publication bias |
Withdrawals | OR 0.78 [0.71, 0.85] | 15 studies · 10150 participants | High |