Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

449 questions · 459 findings · 247 reviews

No studies found 75 · 16.3%GRADE not reported 13 · 2.8%Very low 119 · 25.9%Low 139 · 30.3%Moderate 86 · 18.7%High 27 · 5.9%

Fixed‐dose combination aclidinium/formoterol vs placebo

Non‐fatal serious adverse events · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol showed no clear difference in non‐fatal serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Chondroitin vs placebo

Number of serious adverse events · patients with osteoarthritis

Chondroitin probably leads to lower number of serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Radix Sophorae flavescentis vs placebo or no intervention

Non‐serious adverse events Maximum · chronic hepatitis B

It is very uncertain whether radix Sophorae flavescentis changes proportion of participants with 1 or more adverse events considered… compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Valproate vs placebo

Serious adverse events by 6 weeks · people with agitation in dementia

It is very uncertain whether valproate preparations changes serious adverse events by 6 weeks compared with placebo (very low certainty).

1 finding from 1 review

Celecoxib vs placebo

Short‐term serious adverse events · patients with rheumatoid arthritis

Celecoxib showed no clear difference in short‐term serious adverse events compared with placebo (low certainty).

1 finding from 1 review

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies (EpAbs) vs saline placebo

Serious adverse events (by day 28) · individuals with moderate or severe COVID‐19

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in serious adverse events (by day 28) compared with saline placebo (low certainty).

1 finding from 1 review