Cochrane · systematic review · CD010952
Non‐steroidal anti‐inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and non‐radiographic axial spondyloarthritis)
Kroon, FPB, van der Burg, LRA, Ramiro, S, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
10
No studies
4
Included studies
NR
No studies 4 · 28.6%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 7.1%Moderate 4 · 28.6%High 5 · 35.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Traditional NSAIDs compared with placebo for axSpA
Population: patients with axSpA (AS and nr‐axSpA)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain on VAS Scale from 0 to 100 mm (higher is worse) Traditional NSAIDs vs placebo | no estimate extracted | 850 participants | High |
Withdrawals due to adverse events Due to adverse events Traditional NSAIDs vs placebo | RR 0.75 [0.46, 1.21] | 1165 participants | High |
BASDAI Scale from 0 to 100 (higher is worse) Traditional NSAIDs vs placebo | no estimate extracted | 190 participants | Moderate Downgraded: imprecision |
BASFI Scale from 0 to 100 (higher is worse) Traditional NSAIDs vs placebo | no estimate extracted | 356 participants | High |
BASMI Scale from 0 to 10 (higher is worse) Traditional NSAIDs vs placebo | no estimate extracted | NR | No studies |
Radiographic progression Mean change in mSASSS. Scale from 0 to 72 (higher is worse) Traditional NSAIDs vs placebo | no estimate extracted | NR | No studies |
Number of serious adverse events Traditional NSAIDs vs placebo | RR 1.69 [0.36, 7.97] | 671 participants | Moderate Downgraded: imprecision |
COX‐2 NSAIDs compared with placebo for axSpA
Population: patients with axSpA (AS and nr‐axSpA)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain on VAS Scale from 0 to 100 mm (higher is worse) COX‐2 NSAIDs vs placebo | no estimate extracted | 349 participants | High |
Withdrawals due to adverse events COX‐2 NSAIDs vs placebo | RR 2.14 [0.36, 12.56] | 669 participants | Low Downgraded: imprecision, inconsistency |
BASDAI Scale from 0 to 100 (higher is worse) COX‐2 NSAIDs vs placebo | no estimate extracted | 193 participants | Moderate Downgraded: imprecision |
BASFI Scale from 0 to 100 (higher is worse) COX‐2 NSAIDs vs placebo | no estimate extracted | 349 participants | High |
BASMI Scale from 0 to 10 (higher is worse) COX‐2 NSAIDs vs placebo | no estimate extracted | NR | No studies |
Radiographic progression Mean change in mSASSS. Scale from 0 to 72 (higher is worse) COX‐2 NSAIDs vs placebo | no estimate extracted | NR | No studies |
Number of serious adverse events COX‐2 NSAIDs vs placebo | RR 0.92 [0.14, 6.21] | 669 participants | Moderate Downgraded: imprecision |