Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

41 questions · 42 findings · 24 reviews

No studies found 17 · 40.5%GRADE not reported 3 · 7.1%Very low 8 · 19%Low 7 · 16.7%Moderate 4 · 9.5%High 3 · 7.1%

Restorative dental treatment under general anesthesia vs Before treatment (before-after)

Oral health-related quality of life (child and family) · Preschool children in the United Arab Emirates receiving dental general anesthesia

One study found restorative dental treatment under general anesthesia significantly improved oral health-related quality of life for preschool children and their families (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Malocclusion vs No malocclusion

Poor oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)

Malocclusions probably have a negative effect on OHRQoL in adolescents, after adjustment for confounders (moderate certainty).

1 finding from 1 review

Next‐generation ALK inhibitor vs crizotinib

Health‐related quality of life: time to deterioration in composite endpoint (cough, dyspnoea, and chest pain) · advanced anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer

It is very uncertain whether next‐generation ALK inhibitor changes health‐related quality of life: time to deterioration in composite… compared with crizotinib (very low certainty).

1 finding from 1 review

ALK inhibitor vs any cytotoxic chemotherapy

Health‐related quality of life: time to deterioration in composite endpoint (cough, dyspnoea, and chest pain) · advanced anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer

ALK inhibitor leads to lower health‐related quality of life: time to deterioration in composite… compared with any cytotoxic chemotherapy (high certainty).

1 finding from 1 review