What do systematic reviews say?

Any pharmaceutical treatment vs placebo or no treatment

• Interventions for heartburn in pregnancy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

SSRIs or SNRIs vs other antidepressants

• Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Exercise vs pharmacological treatments

• Exercise for depression 2013 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 1 participants
  Moderate

Exercise vs control

• Exercise for depression 2013 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 4 participants
  GRADE not reported

Exercise vs psychological treatment

• Exercise for depression 2013 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 1 participants
  Moderate

Amitriptyline vs placebo

The review found no eligible studies for this question.

• Amitriptyline versus placebo for major depressive disorder 2012 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings for the main comparison: comprehensive care programmes vs usual care

• Comprehensive care programmes for children with medical complexity 2024 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 701 participants
  Low

Trifocal intraocular lenses vs bifocal intraocular lenses after cataract extraction among participants with presbyopia

The review found no eligible studies for this question.

• Trifocal intraocular lenses versus bifocal intraocular lenses after cataract extraction among participants with… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vasopressin receptor antagonists vs placebo or no treatment

• Interventions for chronic non‐hypovolaemic hypotonic hyponatraemia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 297 participants
  Very low

Summary of findings for the main comparison: comprehensive care programmes vs usual care

• Comprehensive care programmes for children with medical complexity 2024 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 207 participants
  Moderate

Antidepressants (trazodone 200 mg/day) vs placebo

• Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes

  short-term (up to 3 months)
  SoF1. Change in QoL short-term (mean Beck Depression Inventory, 0-63, lower better): this single study narratively reported that both intervention and placebo participants were less depressed at trial completion, but…
  1 study · 37 participants
  Very low

Tricyclic antidepressants vs another medication

The review found no eligible studies for this question.

• Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Zinc vs placebo

• Interventions for managing taste disturbances 2017 · Cochrane All outcomes
  Results (health-related quality of life): None of the studies reported data on health-related quality of life. Heckmann 2005 (zinc) reported that signs of depression were less severe (Beck Depression Inventory P<0.05;…
  1 study
  GRADE not reported

Periodontal disease (present) vs Individuals without periodontal disease (by LOA)

Periodontal disease was associated with higher odds of poor OHRQoL (OR 1.15, 95% CI 1.12-1.18; 3 studies; no heterogeneity; ungraded).

• The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… 2020 All outcomes

  Upper-middle-income countries (Brazil); studies 2010-2014
  OR 1.15 [1.12, 1.18]
  3 studies
  GRADE not reported

Single‐dose, preoperative MMC‐EMDA vs single‐dose, postoperative MMC‐PD

The review found no eligible studies for this question.

• Intravesical electromotive drug administration for non‐muscle invasive bladder cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Single‐dose, preoperative MMC‐EMDA vs TURBT alone

The review found no eligible studies for this question.

• Intravesical electromotive drug administration for non‐muscle invasive bladder cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Electrical stimulation (plus standard care) vs sham‐ECT plus standard care

The review found no eligible studies for this question.

• Electrical stimulation for treating pressure ulcers 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Ibuprofen taken pre-emptively (about 1 hour before treatment) vs Ibuprofen taken post-treatment

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  No studies in this comparison reported this outcome.
  0 studies
  No studies found

Summary of findings table ‐ Oral classical immunosuppressants (prednisolone or cyclosporine) vs placebo

• Treatments for alopecia areata: a network meta‐analysis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 36 participants
  Very low

Prefabricated foot orthoses vs shoes

• Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low