Cochrane · systematic review · CD010965
Interventions for chronic non‐hypovolaemic hypotonic hyponatraemia
Nagler, EV, Haller, MC, Van Biesen, W, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 28.6%Low 2 · 28.6%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Vasopressin receptor antagonists versus placebo or no treatment for chronic non‐hypovolaemic hypotonic hyponatraemia
Population: chronic non‐hypovolaemic hypotonic hyponatraemia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death Vasopressin receptor antagonists vs placebo or no treatment | RR 1.11 [0.92, 1.33] | 15 studies · 2330 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Health‐related quality of life ( Vasopressin receptor antagonists vs placebo or no treatment | no estimate extracted | 2 studies · 297 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Length of hospital stay Vasopressin receptor antagonists vs placebo or no treatment | no estimate extracted | 2 studies · 580 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Cognitive function ( Vasopressin receptor antagonists vs placebo or no treatment | no estimate extracted | 5 studies · 1169 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Change from baseline in serum sodium concentration Vasopressin receptor antagonists vs placebo or no treatment | no estimate extracted | 21 studies · 2641 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Serum sodium concentration (response) Vasopressin receptor antagonists vs placebo or no treatment | RR 2.49 [1.95, 3.18] | 18 studies · 2104 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Rapid sodium increase Vasopressin receptor antagonists vs placebo or no treatment | RR 1.67 [1.16, 2.4] | 14 studies · 2058 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |