Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

630 questions · 634 findings · 285 reviews

No studies found 316 · 49.8%GRADE not reported 40 · 6.3%Very low 95 · 15%Low 111 · 17.5%Moderate 60 · 9.5%High 12 · 1.9%

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

Quality of life: respiratory domain · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
1 finding from 1 review

Next‐generation ALK inhibitor vs crizotinib

Health‐related quality of life: time to deterioration in composite endpoint (cough, dyspnoea, and chest pain) · advanced anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer

It is very uncertain whether next‐generation ALK inhibitor changes health‐related quality of life: time to deterioration in composite… compared with crizotinib (very low certainty).

1 finding from 1 review