Cochrane · systematic review · CD010094
Radioiodine therapy versus antithyroid medications for Graves' disease
Ma, C, Xie, J, Wang, H, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 57.1%Very low 2 · 28.6%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Health‐related quality of life [measured by the validated questionnaire SF‐36] | no estimate extracted | 2 studies · 425 participants | Ungraded |
Development and worsening of Graves' ophthalmopathy [examination by ophthalmologists] | RR 1.94 [1.4, 2.7] | 2 studies · 417 participants | Low Downgraded: risk of bias, imprecision |
Individuals in euthyroid state [measured by serum thyroid hormone levels within the normal range] | no estimate extracted | 1 study · 112 participants | Ungraded |
Recurrence of hyperthyroidism (relapse) [measured by serum thyroid hormone levels above the normal range after withdrawal of methimazole or end of radioiodine treatment] | RR 0.2 [0.01, 2.66] | 2 studies · 417 participants | Very low Downgraded: imprecision, inconsistency |
Adverse events other than development or worsening of Graves' disease (a) Hypothyroidism [measured by TSH and/or thyroid hormones] (b) Drug reactions | no estimate extracted | 1 study · 104 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
All‐cause mortality | no estimate extracted | 2 studies · 425 participants | Ungraded |
Socioeconomic effects [costs per patient, based on the official hospital reimbursement system in Sweden] | no estimate extracted | 1 study · 112 participants | Ungraded |