Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

320 questions · 333 findings · 159 reviews

No studies found 104 · 31.2%GRADE not reported 44 · 13.2%Very low 66 · 19.8%Low 57 · 17.1%Moderate 45 · 13.5%High 17 · 5.1%

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Disease‐specific quality of life · men with urinary incontinence following prostate surgery

Combinations of conservative treatments showed no clear difference in condition‐specific quality of life: using validated questionnaires,… compared with no treatment, sham treatment or verbal/written instruction (moderate certainty).

1 finding from 1 review

Intervention not reported

HRQoL Using EQ‐5D (range 0 to 1) and HOOS (range 0 to 100). A higher score indicates better quality of life. · adults following hip fracture surgery

It is very uncertain whether the intervention changes HRQoL Using EQ‐5D (range 0 to 1) and HOOS (range 0 to 100). A higher… (very low certainty).

1 finding from 1 review

Pilocarpine vs no treatment/placebo

Quality of life (McMaster HNRQ, 1-7 scale) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

It is very uncertain whether pilocarpine changes quality of life (McMaster HNRQ, 1-7 scale) compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Intervention not reported

HRQoL using EQ‐ 5D (range 0 to 1), SF‐36 (range 0 to 100), SF‐12 (range 0 to 100), and WHOQOL‐BREF (range 0 to 130). A higher score indicates better quality of life. · adults following hip fracture surgery

The intervention showed no clear difference in HRQoL using EQ‐ 5D (range 0 to 1), SF‐36 (range 0 to 100), SF‐12… (moderate certainty).

1 finding from 1 review

Antimicrobial lozenge vs placebo

Quality of life and other oral related symptoms · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Quality of life (1 to 6 months post intervention) · adult patients with harmful or hazardous alcohol or substance use

Primary health professional‐ and community professional‐led… showed no clear difference in quality of life (1 to 6 months post intervention) compared with enhanced usual care (moderate certainty).

1 finding from 1 review

Amifostine vs no treatment/placebo

Quality of life (Patient Benefit Questionnaire, 10-point scale) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

It is very uncertain whether amifostine changes quality of life (Patient Benefit Questionnaire, 10-point scale) compared with no treatment/placebo (very low certainty).

1 finding from 1 review