What do systematic reviews say?

Aerobic exercise vs no exercise or placebo exercise

• Exercise training for adults undergoing maintenance dialysis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 306 participants
  Very low

Resistance training vs no exercise or placebo exercise

• Exercise training for adults undergoing maintenance dialysis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 176 participants
  Very low

Aerobic exercise and strength training vs no exercise or placebo exercise

• Exercise training for adults undergoing maintenance dialysis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 228 participants
  Very low

Exercise vs no exercise or placebo exercise

• Exercise training for adults undergoing maintenance dialysis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  17 studies · 656 participants
  Low

Spironolactone 100 mg vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Finasteride 5 mg to 7.5 mg vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin 500 mg to 2550 mg per day vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Flutamide 250 mg b.i.d. vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Medically assisted hydration vs placebo

• Medically assisted hydration for adults receiving palliative care 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 93 participants
  Very low

Intravenous magnesium sulphate vs placebo

• Magnesium for treating sickle cell disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 202 participants
  Low

Cilostazol vs placebo

• Cilostazol for intermittent claudication 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 1163 participants
  Low

Intravenous magnesium sulphate vs placebo

• Magnesium for treating sickle cell disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 202 participants
  Low

Foam sclerotherapy vs placebo

• Injection sclerotherapy for varicose veins 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 299 participants
  Very low

N‐acetylcysteine (1200 mg) vs placebo

It is very uncertain whether N‐acetylcysteine (1200 mg) changes qoL of participants living with SCD and their caregivers (measured… compared with placebo (very low certainty).

• Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 96 participants
  Very low

Cipaglucosidase plus miglustat vs alglucosidase alfa plus placebo

• Enzyme replacement therapy for late‐onset Pompe disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 121 participants
  Low

Summary of findings ‐ dual therapy: lumacaftor plus ivacaftor (once daily) vs placebo

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1061 participants
  Moderate

DHEA vs placebo or control

• Dehydroepiandrosterone for women in the peri‐ or postmenopausal phase 2015 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 287 participants
  Moderate

Belimumab 10 mg/kg vs placebo

Belimumab 10 mg/kg probably leads to higher change in HRQOL, on SF‐36 PCS score at 52 weeks Improvement in SF‐36… compared with placebo (moderate certainty).

• Belimumab for systemic lupus erythematosus 2021 · Cochrane Headline outcomes only
  MD 1.6 [0.3, 2.9]
  2 studies · 801 participants
  Moderate

Noradrenaline reuptake inhibitors vs placebo

• Selective noradrenaline reuptake inhibitors for schizophrenia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 114 participants
  Very low

Chinese herbal medicines vs placebo

• Chinese herbal medicine for menopausal symptoms 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 256 participants
  Low