Cochrane · systematic review · CD001732
Injection sclerotherapy for varicose veins
de Ávila Oliveira, R, Riera, R, Vasconcelos, V, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
VascularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
24
current version
GRADE rated
12
No studies
12
Included studies
NR
No studies 12 · 50%Ungraded 0 · 0%Very low 9 · 37.5%Low 2 · 8.3%Moderate 1 · 4.2%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Foam sclerotherapy versus placebo for treating varicose veins
Population: participants with varicose veinsa
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cosmetic appearance (IPR‐V) (Scale from: 0 to 4; 0 being the best appearance (0: none, 1: mild, 2: moderate, 3: severe, 4: very severe)) Foam sclerotherapy vs placebo | no estimate extracted | 2 studies · 223 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Complications ‐ DVT Foam sclerotherapy vs placebo | RR 5.1 [1.3, 20.01] | 3 studies · 302 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Residual varicose veins Foam sclerotherapy vs placebo | RR 0.19 [0.13, 0.29] | 2 studies · 225 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
QoL (VEINES‐QOL/Sym;scale from: 0 to 50 with 0 being the worst and 50 better) Foam sclerotherapy vs placebo | no estimate extracted | 3 studies · 299 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Persistence of symptoms (VCSS) Foam sclerotherapy vs placebo | no estimate extracted | 2 studies · 223 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Recurrent varicose veins Foam sclerotherapy vs placebo | no estimate extracted | NR | No studies |
Foam sclerotherapy versus foam sclerotherapy for treating varicose veins
Population: participants with varicose veinsa
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cosmetic appearance (self‐described cosmetic improvement) Foam sclerotherapy vs foam sclerotherapy | RR 1.11 [0.84, 1.47] | 1 study · 80 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Complications ‐ thromboembolic Foam sclerotherapy vs foam sclerotherapy | RR 1.47 [0.41, 5.33] | 3 studies · 371 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Residual varicose veins Foam sclerotherapy vs foam sclerotherapy | RR 0.67 [0.43, 1.04] | 3 studies · 371 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
QoL Foam sclerotherapy vs foam sclerotherapy | no estimate extracted | NR | No studies |
Persistence of symptoms Foam sclerotherapy vs foam sclerotherapy | no estimate extracted | NR | No studies |
Recurrent varicose veins Foam sclerotherapy vs foam sclerotherapy | RR 0.91 [0.62, 1.32] | 1 study · 148 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Foam sclerotherapy versus liquid sclerotherapy for treating varicose veins
Population: participants with varicose veinsa
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cosmetic appearance (patient satisfaction scale, the higher the better) Foam sclerotherapy vs liquid sclerotherapy | no estimate extracted | 1 study · 126 participants | Very low Downgraded: risk of bias |
Complications ‐ DVT Foam sclerotherapy vs liquid sclerotherapy | no estimate extracted | NR | No studies |
Residual varicose veins Foam sclerotherapy vs liquid sclerotherapy | RR 0.51 [0.41, 0.65] | 2 studies · 203 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
QoL Foam sclerotherapy vs liquid sclerotherapy | no estimate extracted | NR | No studies |
Persistence of symptoms Foam sclerotherapy vs liquid sclerotherapy | no estimate extracted | NR | No studies |
Recurrent varicose veins Foam sclerotherapy vs liquid sclerotherapy | RR 1.1 [0.86, 1.42] | 1 study · 286 participants | Very low Downgraded: risk of bias |
Sclerotherapy versus sclerotherapy with different substances for treating varicose veins
Population: participants with varicose veinsb
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cosmetic appearance Sclerotherapy vs sclerotherapy with different substances | no estimate extracted | NR | No studies |
Complications ‐ DVT Sclerotherapy vs sclerotherapy with different substances | no estimate extracted | NR | No studies |
Residual varicose veins Sclerotherapy vs sclerotherapy with different substances | no estimate extracted | NR | No studies |
QoL Sclerotherapy vs sclerotherapy with different substances | no estimate extracted | NR | No studies |
Persistence of symptoms Sclerotherapy vs sclerotherapy with different substances | no estimate extracted | NR | No studies |
Recurrent varicose veins Sclerotherapy vs sclerotherapy with different substances | no estimate extracted | NR | No studies |