Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

101 questions · 120 findings · 32 reviews

No studies found 15 · 12.5%GRADE not reported 14 · 11.7%Very low 27 · 22.5%Low 39 · 32.5%Moderate 12 · 10%High 13 · 10.8%

NSAIDs vs placebo

Adequate pain relief as reported by women · women with perineal pain in the early postpartum period

NSAID may leads to higher adequate pain relief(4 hours after administration) compared with placebo (low certainty).

2 findings from 1 review

Paracetamol vs placebo

Relief of pain · women who have given birth vaginally, requiring analgesia for after‐birth pains.

It is very uncertain whether paracetamol changes adequate pain relief as reported by the woman (6 hours) compared with placebo (very low certainty).

1 finding from 1 review

Local anaesthetic injection vs no treatment/placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · septal surgery

The review found no eligible studies for this question.

3 findings from 1 review

Sphenopalatine ganglion block vs no treatment/placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · septal surgery

The review found no eligible studies for this question.

3 findings from 1 review

NSAIDs vs placebo

Relief of pain · women who have given birth vaginally, requiring analgesia for after‐birth pains.

NSAID probably leads to higher adequate pain relief as reported by the woman (5 to 8 hours) compared with placebo (moderate certainty).

1 finding from 1 review

Opioids vs placebo

Relief of pain · women who have given birth vaginally, requiring analgesia for after‐birth pains.

Opioid showed no clear difference in adequate pain relief as reported by the woman (5 to 8 hours) compared with placebo (low certainty).

1 finding from 1 review

Aspirin vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · women with perineal pain in the early postpartum period

Aspirin may leads to higher adequate pain relief as reported by the woman (4 to 8 hours) compared with placebo (low certainty).

1 finding from 1 review

NSAIDs vs placebo

Function: ≥ 50% improvement in pain with movement at 24 hours · acute gout

NSAIDs showed no clear difference in function: ≥ 50% improvement in pain with movement at 24 hours compared with placebo (low certainty).

1 finding from 1 review

NSAIDs vs placebo

Participant‐reported pain relief of 50% or greater · acute gout

NSAIDs may leads to higher pain: ≥ 50% improvement in pain (spontaneous pain at 24 hours) compared with placebo (low certainty).

1 finding from 1 review