Cochrane · systematic review · CD011352
Oral non‐steroidal anti‐inflammatory drugs (single dose) for perineal pain in the early postpartum period
Wuytack, F, Smith, V, Cleary, BJ · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
10
No studies
2
Included studies
NR
No studies 2 · 14.3%Ungraded 2 · 14.3%Very low 5 · 35.7%Low 4 · 28.6%Moderate 1 · 7.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsNSAID compared with placebo for perineal pain in the early postpartum period
Population: women with perineal pain in the early postpartum period
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Adequate pain relief(4 hours after administration) NSAID vs placebo | RR 1.91 [1.64, 2.23] | 10 studies · 1573 participants | Low Downgraded: risk of bias, publication bias |
Adequate pain relief(6 hours after administration) NSAID vs placebo | RR 1.92 [1.69, 2.17] | 17 studies · 2079 participants | Very low Downgraded: risk of bias, publication bias |
Need for additional analgesia(4 hours after administration) NSAID vs placebo | RR 0.39 [0.26, 0.58] | 4 studies · 486 participants | Moderate Downgraded: risk of bias, imprecision |
Need for additional analgesia (6 hours after administration) NSAID vs placebo | RR 0.32 [0.26, 0.4] | 10 studies · 1012 participants | Very low Downgraded: risk of bias, publication bias |
Maternal drug adverse effects(4 hours after administration) NSAID vs placebo | no estimate extracted | 1 study · 90 participants | Ungraded |
Maternal drug adverse effects(6 hours after administration) NSAID vs placebo | RR 1.38 [0.71, 2.7] | 13 studies · 1388 participants | Low Downgraded: risk of bias |
Neonatal drug adverse effects NSAID vs placebo | no estimate extracted | NR | No studies |
NSAID (single administration, any dose) compared to paracetamol for perineal pain in the early postpartum period
Population: women with perineal pain in the early postpartum period
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Adequate pain relief (4 hours after administration) NSAID (single administration, any dose) vs paracetamol | RR 1.54 [1.07, 2.22] | 3 studies · 342 participants | Low Downgraded: risk of bias, imprecision |
Adequate pain relief (6 hours after administration) NSAID (single administration, any dose) vs paracetamol | RR 1.82 [0.61, 5.47] | 2 studies · 99 participants | Very low Downgraded: risk of bias, imprecision |
Need for additional analgesia (4 hours after administration) NSAID (single administration, any dose) vs paracetamol | RR 0.55 [0.27, 1.13] | 1 study · 73 participants | Very low Downgraded: risk of bias, imprecision |
Need for additional analgesia (6 hours after administration) NSAID (single administration, any dose) vs paracetamol | RR 0.28 [0.12, 0.67] | 1 study · 59 participants | Low Downgraded: risk of bias, imprecision |
Maternal drug adverse effects (4 hours after administration) NSAID (single administration, any dose) vs paracetamol | no estimate extracted | 1 study · 210 participants | Ungraded |
Maternal drug adverse effects (6 hours after administration) NSAID (single administration, any dose) vs paracetamol | RR 0.74 [0.27, 2.08] | 3 studies · 300 participants | Very low Downgraded: risk of bias, imprecision |
Neonatal drug adverse effects ‐ not reported NSAID (single administration, any dose) vs paracetamol | no estimate extracted | NR | No studies |