Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

55 questions · 56 findings · 19 reviews · Headline outcomes only

No studies found 3 · 5.4%GRADE not reported 0 · 0%Very low 5 · 8.9%Low 12 · 21.4%Moderate 27 · 48.2%High 9 · 16.1%

Hysterectomy (simple or radical) with radiotherapy vs Radiotherapy alone

Death (all causes) · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with radiotherapy showed no clear difference in overall survival Median compared with radiotherapy alone (low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with chemoradiotherapy vs chemoradiotherapy alone

Death (all causes) · women with locally advanced cervical cancer

It is very uncertain whether hysterectomy (simple or radical) with chemoradiotherapy changes overall survival Median compared with chemoradiotherapy alone (very low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with chemoradiotherapy vs internal radiotherapy (brachytherapy) with chemoradiotherapy

Death (all causes) · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with chemoradiotherapy showed no clear difference in overall survival Median compared with internal radiotherapy (brachytherapy) with chemoradiotherapy (low certainty).

1 finding from 1 review

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery

Overall survival · people with single or solitary brain metastasis

It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes overall survival compared with stereotactic radiosurgery (very low certainty).

1 finding from 1 review

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery plus WBRT

Overall survival · people with single or solitary brain metastasis

Surgery plus whole brain radiotherapy (WBRT) showed no clear difference in overall survival compared with stereotactic radiosurgery plus WBRT (low certainty).

1 finding from 1 review

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

Overall survival for subgroup age 60 years and older glioblastoma · high‐grade glioma

Hypofractionated radiotherapy showed no clear difference in overall survival for subgroup aged ≥ 60 years glioblastoma compared with daily conventionally fractionated radiotherapy (high certainty).

1 finding from 1 review

Summary of findings table ‐ Postmastectomy radiotherapy (PMRT) vs no PMRT

Overall survival (OS) · women with breast cancer and one to three positive lymph nodes

Summary of findings table ‐ Postmastectomy radiotherapy (PMRT) probably leads to lower overall survival (OS) compared with no PMRT (moderate certainty).

1 finding from 1 review

Perioperative chemotherapy vs primary surgery

Overall survival by chemo‐/radiotherapy ‐ Chemotherapy only · resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus

Perioperative chemotherapy leads to lower overall survival by chemo‐/radiotherapy ‐ Chemotherapy only compared with primary surgery (high certainty).

1 finding from 1 review

Perioperative chemotherapy vs primary surgery

Overall survival by chemo‐/radiotherapy ‐ Chemoradiotherapy · resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus

Perioperative chemotherapy probably leads to lower overall survival by chemo‐/radiotherapy ‐ Chemoradiotherapy compared with primary surgery (moderate certainty).

1 finding from 1 review