Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

62 questions · 62 findings · 31 reviews

No studies found 19 · 30.6%GRADE not reported 2 · 3.2%Very low 19 · 30.6%Low 10 · 16.1%Moderate 7 · 11.3%High 5 · 8.1%

Epidural pain relief vs systemic opioid‐based pain relief

Mortality in hospital or up to 30 days · people undergoing abdominal aortic surgery

Epidural pain relief showed no clear difference in mortality in hospital or up to 30 days compared with systemic opioid‐based pain relief (low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Early all‐cause mortality (within 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers showed no clear difference in early all‐cause mortality (within 30 days) compared with placebo or standard care (low certainty).

1 finding from 1 review

Nitroglycerin vs no treatment

All‐cause mortality in 30 days post operation · patients (15 years of age and older) undergoing non‐cardiac surgery under any type of anaesthesia

It is very uncertain whether nitroglycerin changes all‐cause mortality in 30 days post operation compared with no treatment (very low certainty).

1 finding from 1 review

Nitroglycerin vs placebo

All‐cause mortality in 30 days post operation · patients (15 years of age and older) undergoing non‐cardiac surgery under any type of anaesthesia

It is very uncertain whether nitroglycerin changes all‐cause mortality in 30 days post operation compared with placebo (very low certainty).

1 finding from 1 review

Preoperative inspiratory muscle training vs usual care, non‐exercise intervention

Mortality In the early postoperative period (≤ 30 days) · adult participants undergoing cardiac and major abdominal surgery

It is very uncertain whether preoperative inspiratory muscle training changes all‐cause mortality within 30 days during postoperative period compared with usual care, non‐exercise intervention (very low certainty).

1 finding from 1 review

Prophylactic corticosteroids vs placebo or no corticosteroids

Mortality within the longest · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with cardiopulmonary bypass

Prophylactic corticosteroids showed no clear difference in all‐cause mortality (during the index hospital admission, or within… compared with placebo or no corticosteroids (low certainty).

1 finding from 1 review

Intervention not reported

Early mortality (90 days) · patients with diffuse emphysema

The intervention probably leads to higher early mortality (90 days) (moderate certainty).

1 finding from 1 review

Laparoscopic vs open surgery

Late overall mortality (after the first 30 postoperative days) · patients with sigmoid diverticulitis

It is very uncertain whether laparoscopic changes late overall mortality (after the first 30 postoperative days) compared with open surgery (very low certainty).

1 finding from 1 review