Cochrane · systematic review · CD001888
Cell salvage for minimising perioperative allogeneic blood transfusion in adults undergoing elective surgery
Lloyd, TD, Geneen, LJ, Bernhardt, K, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
InjuriesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
63
current version
GRADE rated
46
No studies
17
Included studies
NR
No studies 17 · 27%Ungraded 0 · 0%Very low 34 · 54%Low 9 · 14.3%Moderate 3 · 4.8%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Cell salvage compared to no cell salvage in cancer surgery
Population: cancer surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Transfusions (during hospital stay) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
Volume (PPT) (during hospital stay) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
Mortality (up to 90 days) Cell salvage vs no cell salvage | RR 0.56 [0.11, 2.8] | 2 studies · 79 participants | Very low Downgraded: imprecision |
DVT (up to 90 days) Cell salvage vs no cell salvage | RR 0.5 [0.05, 4.81] | 1 study · 24 participants | Very low Downgraded: imprecision |
Infection (up to 90 days) Cell salvage vs no cell salvage | RR 0.77 [0.4, 1.5] | 1 study · 55 participants | Very low Downgraded: imprecision |
MI (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
CVA (stroke) (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
Cell salvage compared to no cell salvage in cardiovascular (vascular) surgeries
Population: cardiovascular (vascular) surgeries
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Transfusions (during hospital stay) Cell salvage vs no cell salvage | RR 0.61 [0.32, 1.15] | 4 studies · 266 participants | Very low Downgraded: imprecision, inconsistency |
Volume of transfusion (units) (PPT) (during hospital stay) Cell salvage vs no cell salvage | no estimate extracted | 2 studies · 74 participants | Low Downgraded: risk of bias, imprecision |
Mortality (up to 90 days) Cell salvage vs no cell salvage | 1.19 [0.39, 3.65] | 6 studies · 384 participants | Very low Downgraded: imprecision |
DVT (up to 90 days) Cell salvage vs no cell salvage | RD 0 | 1 study · 100 participants | Very low Downgraded: imprecision |
Infection (up to 90 days) Cell salvage vs no cell salvage | RR 0.23 [0.03, 1.98] | 2 studies · 117 participants | Very low Downgraded: imprecision |
MI (up to 90 days) Cell salvage vs no cell salvage | 0.76 [0.17, 3.41] | 3 studies · 203 participants | Very low Downgraded: imprecision |
CVA (stroke) (up to 90 days) Cell salvage vs no cell salvage | 0.14 [0, 6.82] | 1 study · 100 participants | Very low Downgraded: imprecision |
Cell salvage compared to no cell salvage in cardiovascular (no bypass) surgeries
Population: cardiovascular (no bypass) surgeries
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Transfusions (during hospital stay) Cell salvage vs no cell salvage | RR 0.82 [0.69, 0.97] | 3 studies · 169 participants | Moderate Downgraded: risk of bias |
Volume of transfusion (units) (PPT) (during hospital stay) Cell salvage vs no cell salvage | no estimate extracted | 2 studies · 56 participants | Low Downgraded: risk of bias |
Mortality (up to 90 days) Cell salvage vs no cell salvage | 0.13 [0.01, 2.07] | 4 studies · 209 participants | Very low Downgraded: imprecision |
DVT (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
Infection (up to 90 days) Cell salvage vs no cell salvage | 2.06 [0.21, 20.61] | 2 studies · 110 participants | Very low Downgraded: risk of bias, imprecision |
MI (up to 90 days) Cell salvage vs no cell salvage | 1.98 [0.2, 19.32] | 2 studies · 120 participants | Very low Downgraded: imprecision, inconsistency |
CVA (stroke) (up to 90 days) Cell salvage vs no cell salvage | 0.98 [0.06, 15.72] | 3 studies · 160 participants | Very low Downgraded: imprecision, inconsistency |
Cell salvage compared to no cell salvage in cardiovascular (with bypass) surgeries
Population: cardiovascular (with bypass) surgeries
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Transfusions (during hospital stay) Cell salvage vs no cell salvage | RR 0.81 [0.73, 0.89] | 25 studies · 2676 participants | Low Downgraded: inconsistency |
Volume of transfusion (units) (PPT) (during hospital stay) Cell salvage vs no cell salvage | no estimate extracted | 16 studies · 1264 participants | Very low Downgraded: inconsistency |
Mortality (up to 90 days) Cell salvage vs no cell salvage | RR 0.86 [0.5, 1.48] | 21 studies · 2491 participants | Very low Downgraded: imprecision |
DVT (up to 90 days) Cell salvage vs no cell salvage | RD 0 | 1 study · 30 participants | Very low Downgraded: imprecision |
Infection (up to 90 days) Cell salvage vs no cell salvage | RR 1.16 [0.83, 1.61] | 8 studies · 1231 participants | Low Downgraded: risk of bias, imprecision |
MI (up to 90 days) Cell salvage vs no cell salvage | 0.86 [0.47, 1.58] | 9 studies · 1376 participants | Very low Downgraded: risk of bias, imprecision |
CVA (stroke) (up to 90 days) Cell salvage vs no cell salvage | RR 0.54 [0.23, 1.24] | 5 studies · 1018 participants | Moderate Downgraded: imprecision |
Cell salvage compared to no cell salvage in obstetrics
Population: obstetric surgeries
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Transfusions (during hospital stay) Cell salvage vs no cell salvage | 0.82 [0.38, 1.76] | 1 study · 1349 participants | Low Downgraded: imprecision |
Volume of transfusion (units) (PPT) (during hospital stay) Cell salvage vs no cell salvage | no estimate extracted | 1 study · 27 participants | Low Downgraded: imprecision |
Mortality (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
DVT (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
Infection (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
MI (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
CVA (stroke) (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
Cell salvage compared to no cell salvage in orthopaedic (hip) surgeries
Population: orthopaedic (hip)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Transfusions (during hospital stay) Cell salvage vs no cell salvage | RR 0.52 [0.38, 0.72] | 14 studies · 1641 participants | Very low Downgraded: risk of bias, inconsistency |
Volume of transfusion (units) (PPT) (during hospital stay) Cell salvage vs no cell salvage | no estimate extracted | 4 studies · 63 participants | Very low Downgraded: risk of bias, imprecision |
Mortality (up to 90 days) Cell salvage vs no cell salvage | 0.46 [0.06, 3.33] | 4 studies · 651 participants | Very low Downgraded: risk of bias, imprecision |
DVT (up to 90 days) Cell salvage vs no cell salvage | 1.05 [0.2, 5.6] | 3 studies · 343 participants | Very low Downgraded: risk of bias, imprecision |
Infection (up to 90 days) Cell salvage vs no cell salvage | 0.72 [0.17, 2.98] | 4 studies · 549 participants | Very low Downgraded: risk of bias, imprecision |
MI (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
CVA (stroke) (up to 90 days) Cell salvage vs no cell salvage | RR 3 [0.13, 68.26] | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |
Cell salvage compared to no cell salvage in orthopaedic (knee) surgeries
Population: orthopaedic (knee)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Transfusions (during hospital stay) Cell salvage vs no cell salvage | RR 0.49 [0.37, 0.66] | 21 studies · 2214 participants | Very low Downgraded: risk of bias, inconsistency |
Volume of transfusion (units) (PPT) (during hospital stay) Cell salvage vs no cell salvage | no estimate extracted | 3 studies · 221 participants | Very low Downgraded: risk of bias, inconsistency |
Mortality (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
DVT (up to 90 days) Cell salvage vs no cell salvage | 1.29 [0.56, 2.95] | 9 studies · 793 participants | Very low Downgraded: risk of bias, imprecision |
Infection (up to 90 days) Cell salvage vs no cell salvage | 0.74 [0.28, 1.94] | 5 studies · 730 participants | Very low Downgraded: risk of bias, imprecision |
MI (up to 90 days) Cell salvage vs no cell salvage | 7.02 [0.14, 354.4] | 1 study · 115 participants | Very low Downgraded: imprecision |
CVA (stroke) (up to 90 days) Cell salvage vs no cell salvage | RD 0 | 1 study · 60 participants | Low Downgraded: risk of bias, imprecision |
Cell salvage compared to no cell salvage in orthopaedic (spinal) surgeries
Population: orthopaedic (spinal)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Transfusions (during hospital stay) Cell salvage vs no cell salvage | RR 0.44 [0.31, 0.63] | 3 studies · 194 participants | Moderate Downgraded: risk of bias |
Volume of transfusion (units) (PPT) (during hospital stay) Cell salvage vs no cell salvage | no estimate extracted | 1 study · 45 participants | Very low Downgraded: risk of bias, imprecision |
Mortality (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
DVT (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
Infection (up to 90 days) Cell salvage vs no cell salvage | RD 0 | 1 study · 63 participants | Low Downgraded: risk of bias, imprecision |
MI (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
CVA (stroke) (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |
Cell salvage compared to no cell salvage in orthopaedic (mixed) surgeries
Population: orthopaedic (mixed)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Transfusions (during hospital stay) Cell salvage vs no cell salvage | RR 0.64 [0.45, 0.9] | 11 studies · 4011 participants | Very low Downgraded: risk of bias, inconsistency |
Volume of transfusion (units) (PPT) (during hospital stay) Cell salvage vs no cell salvage | no estimate extracted | 5 studies · 395 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Mortality (up to 90 days) Cell salvage vs no cell salvage | RD 0 | 1 study · 69 participants | Very low Downgraded: imprecision |
DVT (up to 90 days) Cell salvage vs no cell salvage | OR 0.41 [0.09, 1.92] | 4 studies · 3295 participants | Low Downgraded: imprecision |
Infection (up to 90 days) Cell salvage vs no cell salvage | RD 0 | 1 study · 239 participants | Very low Downgraded: risk of bias, imprecision |
MI (up to 90 days) Cell salvage vs no cell salvage | OR 0.62 [0.17, 2.22] | 2 studies · 3017 participants | Very low Downgraded: imprecision |
CVA (stroke) (up to 90 days) ‐ not reported Cell salvage vs no cell salvage | no estimate extracted | NR | No studies |