Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

116 questions · 122 findings · 53 reviews · Headline outcomes only

No studies found 34 · 27.9%GRADE not reported 13 · 10.7%Very low 22 · 18%Low 39 · 32%Moderate 11 · 9%High 3 · 2.5%

Multiple doses of deworming drugs vs placebo

Death (between ages 1 and 6 years) · public health programmes to regularly treat all children aged 16 years or less

Multiple doses of deworming drugs showed no clear difference in mortality (between ages 1 and 6 years) compared with placebo (low certainty).

1 finding from 1 review

Case management for integrated care vs usual care of older people living with frailty

All‐cause mortality · people aged 65 years and older living with frailty

Case management for integrated care showed no clear difference in mortality compared with usual care of older people living with frailty (low certainty).

1 finding from 1 review

Tetanus diphtheria toxoid immunisation of women of reproductive age vs cholera toxoid

Neonatal mortality between day 4‐14 of life · women of reproductive age ≥ 15 years.

Tetanus diphtheria toxoid immunisation of women of reproductive age may leads to lower neonatal mortality between day 4‐14 of life compared with cholera toxoid (low certainty).

1 finding from 1 review

Tetanus diphtheria toxoid immunisation of women of reproductive age vs cholera toxoid

Neonatal death (death within the first 28 days of life) · women of reproductive age ≥ 15 years.

Tetanus diphtheria toxoid immunisation of women of reproductive age may leads to lower neonatal mortality in the first 28 days of life compared with cholera toxoid (low certainty).

1 finding from 1 review

High‐dose vs standard‐dose strategies

Mortality or major neurodevelopmental disability in children aged 18 to 24 months and 3 to 5 years CA · preterm infants with or at risk for apnea of prematurity

The review found no eligible studies for this question.

3 findings from 1 review