Cochrane · systematic review · CD009085
Intermittent iron supplementation for improving nutrition and development in children under 12 years of age
De‐Regil, LM, Jefferds, MED, Sylvetsky, AC, et al. · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 33.3%Very low 2 · 16.7%Low 5 · 41.7%Moderate 1 · 8.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intermittent use of iron supplements versus placebo or no intervention in children younger than 12 years of age
Population: children under 12 years of age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Anaemia (haemoglobin below a cut‐off defined by trialists, taking into account the age and altitude) Â Intermittent use of iron supplements vs placebo or no intervention | RR 0.51 [0.37, 0.72] | 10 studies · 1824 participants | Moderate |
Haemoglobin (g/L) Intermittent use of iron supplements vs placebo or no intervention | MD 5.2 [2.51, 7.88] | 19 studies · 3032 participants | Low |
Iron deficiency (using ferritin concentrations) Intermittent use of iron supplements vs placebo or no intervention | RR 0.24 [0.06, 0.91] | 3 studies · 431 participants | Very low |
Iron status (ferritin (μg/L) Intermittent use of iron supplements vs placebo or no intervention | MD 14.17 [3.53, 24.81] | 5 studies · 550 participants | Low |
Iron deficiency anaemia Intermittent use of iron supplements vs placebo or no intervention | no estimate extracted | 0 studies · 0 participants | Ungraded |
All‐cause mortality Intermittent use of iron supplements vs placebo or no intervention | no estimate extracted | 0 studies · 0 participants | Ungraded |
Intermittent versus daily use of iron supplements in children younger than 12 years of age
Population: children under 12 years of age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Anaemia (haemoglobin below a cut‐off defined by trialists, taking into account the age and altitude) Intermittent vs daily use of iron supplements | RR 1.23 [1.04, 1.47] | 6 studies · 980 participants | Low |
Haemoglobin (g/L) Intermittent vs daily use of iron supplements | no estimate extracted | 19 studies · 2851 participants | Low |
Iron deficiency (using ferritin concentrations) Intermittent vs daily use of iron supplements | RR 4 [1.23, 13.05] | 1 study · 76 participants | Very low |
Iron status (ferritin (µg/L) Intermittent vs daily use of iron supplements | no estimate extracted | 10 studies · 902 participants | Low |
Iron deficiency anaemia Intermittent vs daily use of iron supplements | no estimate extracted | 0 studies · 0 participants | Ungraded |
Mortality Intermittent vs daily use of iron supplements | no estimate extracted | 0 studies · 0 participants | Ungraded |