Cochrane · systematic review · CD002959
Vaccines for women for preventing neonatal tetanus
Demicheli, V, Barale, A, Rivetti, A · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 28.6%Moderate 10 · 71.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Tetanus toxoid versus influenza vaccine for women to prevent neonatal tetanus
Population: women aged between 13 and 45 years.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Neonatal tetanus deaths ‐ 1 dose Tetanus toxoid vs influenza vaccine | RR 0.57 [0.26, 1.24] | 1 study · 494 participants | Low Downgraded: risk of bias, imprecision |
Neonatal tetanus deaths ‐ 2 or 3 doses Tetanus toxoid vs influenza vaccine | RR 0.02 [0, 0.3] | 1 study · 688 participants | Moderate Downgraded: risk of bias |
All causes of deaths ‐ 1 dose Tetanus toxoid vs influenza vaccine | RR 1.08 [0.65, 1.79] | 1 study · 494 participants | Low Downgraded: risk of bias, imprecision |
All causes of deaths ‐ 2 or 3 doses Tetanus toxoid vs influenza vaccine | RR 0.31 [0.17, 0.55] | 1 study · 688 participants | Moderate Downgraded: risk of bias |
Neonatal tetanus cases ‐ Any dose Tetanus toxoid vs influenza vaccine | RR 0.2 [0.1, 0.4] | 1 study · 1182 participants | Moderate Downgraded: risk of bias |
Tetanus diphtheria toxoid immunisation of women of reproductive age compared with cholera toxoid for preventing neonatal mortality
Population: women of reproductive age ≥ 15 years.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Neonatal mortality in the first 28 days of life Tetanus diphtheria toxoid immunisation of women of reproductive age vs cholera toxoid | RR 0.68 [0.56, 0.82] | 1 study · 8641 participants | Low Downgraded: risk of bias, indirectness |
Neonatal mortality between day 4‐14 of life Tetanus diphtheria toxoid immunisation of women of reproductive age vs cholera toxoid | RR 0.38 [0.27, 0.55] | 1 study · 8641 participants | Low Downgraded: risk of bias, indirectness |
Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine versus saline placebo in pregnant women
Population: patients with local and systemic reactions
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Injection site reactions ‐ pain at injection site Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo | RR 5.68 [1.54, 20.94] | 1 study · 48 participants | Moderate Downgraded: imprecision |
Injection site reactions ‐ erythema ‐ redness Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo | RR 1.36 [0.15, 12.05] | 1 study · 48 participants | Moderate Downgraded: imprecision |
Injection site reactions ‐ induration ‐ swelling Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo | RR 3.29 [0.18, 60.05] | 1 study · 48 participants | Moderate Downgraded: imprecision |
Systemic reactions ‐ fever (oral temperature ≥ 38°C) Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo | RR 1.41 [0.06, 32.78] | 1 study · 48 participants | Moderate Downgraded: imprecision |
Systemic reactions ‐ headache Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo | RR 1.67 [0.54, 5.11] | 1 study · 48 participants | Moderate Downgraded: imprecision |
Systemic reactions ‐ malaise Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo | RR 0.91 [0.19, 4.43] | 1 study · 48 participants | Moderate Downgraded: imprecision |
Systemic reactions ‐ myalgia Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo | RR 5.18 [0.3, 88.02] | 1 study · 48 participants | Moderate Downgraded: imprecision |