Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

13 questions · 13 findings · 9 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 23.1%Low 5 · 38.5%Moderate 3 · 23.1%High 2 · 15.4%

Early discontinuation of antibiotic treatment vs treatment until neutropenia resolution

All‐cause mortality · febrile neutropenia

Early discontinuation of antibiotic treatment showed no clear difference in mortality compared with treatment until neutropenia resolution (low certainty).

1 finding from 1 review

Adverse events with anti‐gram‐positive antibiotics vs placebo

Overall mortality · people with cancer who have febrile neutropenia

Mortality with anti‐gram‐positive antibiotics showed no clear difference in overall mortality compared with placebo (moderate certainty).

1 finding from 1 review

Pre‐emptive antifungal therapy vs empirical antifungal therapy

All‐cause mortality · people with cancer who have febrile neutropenia

Pre‐emptive antifungal therapy showed no clear difference in all‐cause mortality compared with empirical antifungal therapy (low certainty).

1 finding from 1 review

beta‐lactam monotherapy vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

All cause mortality · people with cancer who have febrile neutropenia

beta‐lactam monotherapy showed no clear difference in all cause mortality compared with beta‐lactam‐aminoglycoside combination therapy (high certainty).

1 finding from 1 review

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

All cause‐mortality · cancer patients with afebrile neutropenia following chemotherapy

Summary of findings: quinolone prophylaxis probably leads to higher all cause‐mortality compared with TMP‐SMZ prophylaxis (moderate certainty).

1 finding from 1 review

Pre‐emptive antifungal therapy vs empirical antifungal therapy

Mortality ascribed to fungal infection · people with cancer who have febrile neutropenia

Pre‐emptive antifungal therapy showed no clear difference in mortality ascribed to fungal infection compared with empirical antifungal therapy (low certainty).

1 finding from 1 review