Cochrane · systematic review · CD005341
Granulocyte transfusions for preventing infections in people with neutropenia or neutrophil dysfunction
Estcourt, LJ, Stanworth, SJ, Doree, C, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 4 · 57.1%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: people with neutropenia or neutrophil dysfunction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality up to 30 days | RR 0.92 [0.63, 1.36] | 7 studies · 437 participants | Very low Downgraded: risk of bias, imprecision |
Mortality due to infection up to 30 days | RR 0.69 [0.33, 1.44] | 6 studies · 286 participants | Very low Downgraded: risk of bias, imprecision |
People with localised or systemic bacterial or fungal infections ‐ low‐dose granulocyte transfusions | RR 0.84 [0.58, 1.2] | 4 studies · 204 participants | Very low Downgraded: risk of bias, imprecision |
People with localised or systemic bacterial or fungal infections ‐ Intermediate‐dose granulocyte transfusions | RR 0.4 [0.26, 0.63] | 4 studies · 293 participants | Low Downgraded: risk of bias |
People with bacteraemia or fungaemia | RR 0.45 [0.3, 0.65] | 9 studies · 609 participants | Low Downgraded: risk of bias |
People with localised bacterial or fungal infection | RR 0.75 [0.5, 1.14] | 6 studies · 296 participants | Very low Downgraded: risk of bias, imprecision |
People with serious adverse events | no estimate extracted | NR | No studies |