Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

18 questions · 18 findings · 13 reviews · Emergency and Critical Care

No studies found 2 · 11.1%GRADE not reported 0 · 0%Very low 5 · 27.8%Low 8 · 44.4%Moderate 2 · 11.1%High 1 · 5.6%

Intervention not reported

Combined mortality of all studies · Adult patients in intensive care

The intervention leads to higher combined mortality of all studies (high certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

All‐cause mortality · people requiring tracheal intubation

Oxygenation showed no clear difference in mortality compared with no oxygenation during the apnoeic period preceding intubation (low certainty).

1 finding from 1 review

Enteral vs parenteral nutrition

All‐cause mortality · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

Enteral showed no clear difference in mortality compared with parenteral nutrition (low certainty).

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

All‐cause mortality · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

Enteral showed no clear difference in mortality compared with enteral and parenteral nutrition (low certainty).

1 finding from 1 review

Protocol‐directed sedation management vs usual care

ICU mortality · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in ICU mortality compared with usual care (low certainty).

1 finding from 1 review

Protocol‐directed sedation management vs usual care

Hospital mortality · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in hospital mortality compared with usual care (low certainty).

1 finding from 1 review

Intervention not reported

Mortality at longest · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…

It is very uncertain whether the intervention changes mortality at longest (very low certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

In‐hospital mortality within 28 days. · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

Haloperidol showed no clear difference in in‐hospital mortality within 28 days. compared with placebo (moderate certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

All‐cause mortality: range 1 mo to 1 y · adults admitted to the ICU

It is very uncertain whether higher changes all‐cause mortality: range 1 mo to 1 y compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Physical and cognitive therapy vs usual care

In‐hospital mortality at 30 days or at the longest · critically ill patients 18 years or older treated for respiratory failure or septic or both, cardiogenic or haemorrhagic shock who resided…

It is very uncertain whether physical and cognitive therapy changes in‐hospital mortality at 30 days or at the longest compared with standard care (very low certainty).

1 finding from 1 review

HFNC vs NIPPV or NIV

In‐hospital mortality (up to 90 days; included studies reported in‐hospital mortality, and mortality up to 28 days and up to ICU discharge) · adults in the ICU, requiring respiratory support

HFNC showed no clear difference in in‐hospital mortality (up to 90 days; included studies reported… compared with NIPPV or NIV (low certainty).

1 finding from 1 review

HFNC vs standard oxygen therapy

In‐hospital mortality (up to 90 days; included studies reported in‐hospital mortality, and mortality up to 28 days and up to ICU discharge) · adults in the ICU, requiring respiratory support

HFNC showed no clear difference in in‐hospital mortality (up to 90 days; included studies reported… compared with standard oxygen therapy (moderate certainty).

1 finding from 1 review