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Evidence found and GRADE certainty

155 questions · 159 findings · 87 reviews

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No studies found 18 · 11.3%GRADE not reported 7 · 4.4%Very low 42 · 26.4%Low 44 · 27.7%Moderate 41 · 25.8%High 7 · 4.4%

Summary of findings for the main comparison. Implantable loop recorder vs conventional diagnostic workup

All‐cause long‐term mortality · people with unexplained recurrent syncope

It is very uncertain whether summary of findings for the main comparison. Implantable loop recorder changes all‐cause long‐term mortality compared with conventional diagnostic workup (very low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Mortality within the longest · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in all‐cause mortality (at longest compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Intervention not reported

Mortality (all cause) Long‐term · people with chronic ischaemic heart disease and congestive heart failure

The intervention may leads to lower mortality (all cause) Long‐term (low certainty).

1 finding from 1 review

Cells vs no cells

All‐cause mortality ‐ long‐term · Anyone diagnosed with AMI

Cells showed no clear difference in all‐cause mortality ‐ long‐term compared with no cells (moderate certainty).

1 finding from 1 review

Intervention not reported

Long‐term mortality (> 36 months) · patients with diffuse emphysema

The intervention probably leads to lower long‐term mortality (> 36 months) (moderate certainty).

1 finding from 1 review

Pulmonary artery perfusion with blood vs no perfusion during cardiopulmonary bypass

Mortality within the longest · adult surgical patients with the need for cardiopulmonary bypass‐dependent heart surgery

It is very uncertain whether pulmonary artery perfusion with blood changes all‐cause mortality within longest compared with no perfusion during cardiopulmonary bypass (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Mortality within the longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes all‐cause mortality (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Psychological interventions vs control

Cardiovascular mortality · health problem or population

Summary of findings table ‐ Psychological treatment showed no clear difference in cardiovascular mortality ‐ long‐term compared with control; GRADE not reported.

1 finding from 1 review

Cells vs no cells

Cardiovascular mortality · Anyone diagnosed with AMI

Cells showed no clear difference in cardiovascular mortality ‐ long‐term compared with no cells (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Daratumumab plus standard therapy vs usual care

Mortality within the longest · people with newly diagnosed multiple myeloma ineligible for transplant

Summary of findings table ‐ Daratumumab plus standard therapy probably leads to lower on‐study mortality (longest available compared with standard therapy (moderate certainty).

1 finding from 1 review

Tenofovir‐based antiviral combination regimens vs placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens

All‐cause infant mortality at longest · HIV‐positive pregnant women co‐infected with hepatitis B virus

It is very uncertain whether tenofovir‐based antiviral combination regimens changes all‐cause infant mortality at longest compared with placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens (very low certainty).

1 finding from 1 review

Chronic DVT ‐ antiplatelet agents plus BMP vs BMP plus placebo

Mortality ‐ intermediate and long term · people requiring treatment for chronic DVT

Chronic DVT ‐ antiplatelet agents plus BMP showed no clear difference in mortality ‐ intermediate and long term compared with BMP plus placebo (moderate certainty).

1 finding from 1 review