Cochrane · systematic review · CD013101
Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass
Gibbison, B, Villalobos Lizardi, JC, Avilés Martínez, KI, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 4 · 57.1%High 2 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Glucocorticoid compared to placebo for paediatric heart surgery with cardiopulmonary bypass
Population: Children having heart surgery with cardiopulmonary bypass
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
In‐hospital postoperative mortality Glucocorticoid vs placebo | RR 0.83 [0.33, 2.07] | 5 studies · 313 participants | Moderate Downgraded: imprecision, publication bias |
Duration of postoperative mechanical ventilation Glucocorticoid vs placebo | no estimate extracted | 6 studies · 421 participants | High |
Length of postoperative ICU stay Glucocorticoid vs placebo | no estimate extracted | 6 studies · 421 participants | High |
Length of postoperative hospital stay Glucocorticoid vs placebo | no estimate extracted | 1 study · 176 participants | Moderate Downgraded: imprecision, publication bias |
All‐cause mortality at longest Glucocorticoid vs placebo | RR 0.83 [0.33, 2.07] | 5 studies · 313 participants | Moderate Downgraded: imprecision, publication bias |
Cardiovascular mortality at longest Glucocorticoid vs placebo | RR 0.4 [0.07, 2.46] | 3 studies · 109 participants | Moderate Downgraded: imprecision, publication bias |
Failure to separate from CPB Glucocorticoid vs placebo | RR 0.2 [0.01, 3.92] | 1 study · 40 participants | Low Downgraded: imprecision, publication bias |